AI Article Synopsis
- The study aimed to assess the prevalence of sleep-related disturbances, specifically nocturnal hypoxaemia, in patients with Eisenmenger syndrome.
- The research involved 25 patients with Eisenmenger syndrome and compared them to 12 control patients with similar congenital heart conditions, utilizing overnight polysomnogram studies for data collection.
- Results indicated that both groups experienced significant nocturnal hypoxaemia without apnoea, with higher incidences of oxygen drops linked to elevated haemoglobin levels in Eisenmenger syndrome patients.
Article Abstract
Objectives: The objective of the study was to find the prevalence of sleep-related disturbances in patients of Eisenmenger syndrome.
Design: Prospective observational study.
Setting: Tertiary care referral centre in North India.
Participants: The study included 25 patients with Eisenmenger syndrome (mean age 25.2±9.6 years, 18 men) and 12 patients with cyanotic congenital heart disease with pulmonary stenosis physiology (mean age 20.5±8.5 years, 8 men) as controls.
Interventions: All the patients underwent an overnight comprehensive polysomnogram study and pulmonary function testing.
Main Outcome Measure: Oxygen desaturation index, which is the number of oxygen drops per hour.
Results: The patients and controls had significant nocturnal hypoxaemia in the absence of apnoea and hypopnoea. The mean oxygen drop index in Eisenmenger syndrome group was 9.0±6.2 and in the control group was 8.0±5.9 (p=0.63). The apnoea-hypopnoea index was 3.37±5.0 in the Eisenmenger syndrome group and was 2.1±3.6 in the control group. Patients with >10 oxygen drops per hour had significantly higher haemoglobin (17.2±1.3% vs 14.4±1.5%, p<0.001) than those with oxygen drops less than 10.
Conclusions: Eisenmenger syndrome patients have significant nocturnal hypoxaemia unrelated to hypopnoea and apnoea. Nocturnal desaturation occurred more frequently in patients with greater haemoglobin values.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612812 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2012-002039 | DOI Listing |
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