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Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon.
J Orthop Res
December 2024
McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Exercise influences clinical Achilles tendon health in humans, but animal models of exercise-related Achilles tendon changes are lacking. Moreover, previous investigations of the effects of treadmill running exercise on rat Achilles tendon demonstrate variable outcomes. Our objective was to assess the functional, structural, cellular, and biomechanical impacts of treadmill running exercise on rat Achilles tendon with sensitive in and ex vivo approaches.
View Article and Find Full Text PDFIntegrating electrospun aligned fiber scaffolds with bovine serum albumin-basic fibroblast growth factor nanoparticles to promote tendon regeneration.
J Nanobiotechnology
December 2024
State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Background: Electrospun nanofiber scaffolds have been widely used in tissue engineering because they can mimic extracellular matrix-like structures and offer advantages including high porosity, large specific surface area, and customizable structure. In this study, we prepared scaffolds composed of aligned and random electrospun polycaprolactone (PCL) nanofibers capable of delivering basic fibroblast growth factor (bFGF) in a sustained manner for repairing damaged tendons.
Results: Aligned and random PCL fiber scaffolds containing bFGF-loaded bovine serum albumin (BSA) nanoparticles (BSA-bFGF NPs, diameter 146 ± 32 nm) were fabricated, respectively.
Platelet-rich plasma enhances remodeling of combined gastrocnemius muscle and achilles tendon injuries in rat model: Reducing fibrosis, modulating gene (MMP9, Bax, HMGB1, and IGF) expression, and restoring histopathological and ultrastructural changes.
Tissue Cell
December 2024
Department of Anatomy and Embryology, Faculty of Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt.
Muscle and tendon injuries are prevalent occurrences during sports activities. Platelet-rich plasma (PRP) is known for its rich content of factors essential for wound healing, inflammation reduction, and tissue repair. Despite its recognized benefits, limited information is available regarding PRP's effectiveness in addressing combined surgical injuries to the gastrocnemius muscle and Achilles tendon.
View Article and Find Full Text PDFAchilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch.
J Anat
December 2024
Institute of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg, Germany.
Diabetes mellitus type 2 (DMT2) promotes Achilles tendon (AS) degeneration and exercise could modulate features of DMT2. Hence, this study investigated whether tenocytes of non DMT2 and DMT2 rats respond differently to normo- (NG) and hyperglycemic (HG) conditions in the presence of tumor necrosis factor (TNF)α or cyclic stretch. AS tenocytes, isolated from DMT2 (fa/fa) or non DMT2 (lean, fa/+) adult Zucker Diabetic Fatty (ZDF) rats, were treated with 10 ng/mL TNFα either under NG or HG conditions (1 g/L vs.
View Article and Find Full Text PDFTraction Sural Neuropathy Following Nonoperative Management of Acute Achilles Tendon Rupture: A Case Report.
Cureus
November 2024
Department of Orthopedic Surgery, Division of Sports Medicine, University of California San Diego School of Medicine, La Jolla, USA.
Achilles tendon ruptures are prevalent among physically active adults and can lead to sural nerve injuries (SNIs) due to the anatomical proximity of the sural nerve to the Achilles tendon. While SNIs are well-recognized in surgical contexts, their occurrence following nonoperative treatments, which are often preferred for their lower risk of surgical complications, remains less documented and poorly understood. This report describes a case of a 30-year-old active male who developed chronic traction sural neuropathy after opting for nonoperative treatment of an acute complete Achilles tendon rupture.
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