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Total synthesis of (+)-pentamethylsalvianolic acid C. | LitMetric

Total synthesis of (+)-pentamethylsalvianolic acid C.

Org Biomol Chem

RMIT University, School of Applied Science [Applied Chemistry], Bowen Street, Melbourne, Victoria, Australia.

Published: April 2013

AI Article Synopsis

Article Abstract

The total synthesis of a methylated analogue of (+)-Salvianolic acid C has been achieved. Key aspects of the synthetic route include an economical Cu(I) acetylide coupling, unique carboxyl activation conditions via microwave irradiation and a novel lipase catalysed kinetic resolution of a racemic mixture of secondary alcohol Danshensu. The preparation of this methylated analogue will not only improve the bioavailability, but also enable access to new and wider bioactivity applications for (+)-Salvianolic acid C.

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Source
http://dx.doi.org/10.1039/c3ob27478kDOI Listing

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