Study Design: Retrospective study.
Objective: To evaluate the epidemiology and treatment outcome of spinal cord injuries (SCIs) at three tertiary care centres within southeast Nigeria.
Setting: Southeast Nigeria.
Methods: Causes, seasonal variation, transportation to hospital, severity of injury, treatment and outcome of patients with SCIs treated by the authors at three study locations from September 2009 to August 2012 were studied.
Results: Eighty-five patients with SCI had been admitted during that period to the three hospitals and were qualified for the study. The age range was 2-75 years with a mean of 36.13 years. The 31-45 years age group is the most frequently affected. Altogether, 69 male and 16 female individuals were involved. Motor vehicle accident (MVA) (47, 55.3%) was the most frequent cause of injury. Falls from palm trees (3.5%) were markedly reduced from what they were inferred to be (40.2%) from a similar study in our area in 1988. Injury peaks were observed during major festivities. Only three patients (0.035%) were transported to care centres with an ambulance. Forty patients were classified as being affected by ASIA grade A injury, whereas 45 patients had various ASIA grades of incomplete injury. Sixty-eight patients were managed conservatively; 23 of them improved from their grades, 35 remained the same, 1 worsened, while 9 died. Of 17 patients treated operatively, 9 improved, 5 remained the same, 2 worsened and 1 died.
Conclusion: Currently, SCIs reported in the three main hospitals located in southeast Nigeria are caused mainly by MVAs. SCI affects mainly male individuals and peak frequencies are observed during festivities.
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http://dx.doi.org/10.1038/sc.2013.10 | DOI Listing |
PLoS One
January 2025
Division of Oral Physiology, Faculty of Dentistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
This study examined the effects of treadmill running (TR) regimens on craniofacial pain- and anxiety-like behaviors, as well as their effects on neural changes in specific brain regions of male mice subjected to repeated social defeat stress (SDS) for 10 days. Behavioral and immunohistochemical experiments were conducted to evaluate the impact of TR regimens on SDS-related those behaviors, as well as epigenetic and neural activity markers in the anterior cingulate cortex (ACC), insular cortex (IC), rostral ventromedial medulla (RVM), and cervical spinal dorsal horn (C2). Behavioral responses were quantified using multiple tests, while immunohistochemistry measured histone H3 acetylation, histone deacetylases (HDAC1, HDAC2), and neural activity markers (FosB and phosphorylated cAMP response element-binding protein (pCREB).
View Article and Find Full Text PDFAnn Clin Transl Neurol
January 2025
Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Objective: To characterize structural integrity of the lumbosacral enlargement and conus medullaris within one month after spinal cord injury (SCI).
Methods: Lumbosacral cord MRI data were acquired in patients with sudden onset (<7 days) SCI at the cervical or thoracic level approximately one month after injury and in healthy controls. Tissue integrity and loss were evaluated through diffusion tensor (DTI) and T2*-weighted imaging (cross-sectional area [CSA] measurements).
Curr Pain Headache Rep
January 2025
Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL, 60657, USA.
Purpose Of The Review: In the United States, spinal cord injuries affect approximately 18,000 individuals annually, most commonly resulting from mechanical trauma. The consequent paraplegia severely impairs motor functions, creating an urgent need for innovative therapeutic strategies that extend beyond traditional rehabilitation and pharmacotherapy. This review assesses the effectiveness of Spinal Cord Stimulation (SCS) in improving motor function in patients with spinal cord injuries, with a particular focus on paraplegia.
View Article and Find Full Text PDFBrain Struct Funct
January 2025
Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, 670 W Baltimore St, HSF III, R1173, Baltimore, MD, 21202, USA.
The brain entropy (BEN) reflects the randomness of brain activity and is inversely related to its temporal coherence. In recent years, BEN has been found to be associated with a number of neurocognitive, biological, and sociodemographic variables such as fluid intelligence, age, sex, and education. However, evidence regarding the potential relationship between BEN and brain structure is still lacking.
View Article and Find Full Text PDFNeuromolecular Med
January 2025
Department of Anatomy, School of Basic Medical Sciences, Shanxi Medical University, No 56, Xinjian Nan Road, Taiyuan, 030001, Shanxi, China.
The integrity of the myelin sheath of the spinal cord (SC) is essential for motor coordination. Seipin is an endoplasmic reticulum transmembrane protein highly expressed in adipose tissue and motor neurons in the SC. It was reported Seipin deficiency induced lipid dysregulation and neurobehavioral deficits, but the underlying mechanism, especially in SC, remains to be elucidated.
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