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BACKGROUND Edentulous elderly patients often face challenges in airway management and are susceptible to hypoxemia. Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) provides high-flow nasal oxygenation, potentially extending safe apneic time (SAT). This study compared the efficacy of THRIVE versus facemask ventilation in improving oxygenation and extending SAT in edentulous elderly patients.

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Apnea is common after induction of anesthesia and may produce dangerous hypoxemia, particularly in obese subjects. Optimal management of airway emergencies in obese, apneic subjects is complex and controversial, and clinical studies of rescue strategies are inherently difficult and ethically-challenging to perform. We investigated rescue strategies in various degrees of obesity, using a highly-integrated, computational model of the pulmonary and cardiovascular systems, configured against data from 8 virtual subjects (body mass index [BMI] 24-57 kg m).

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Oxygen Reserve Index: A Novel Noninvasive Measure of Oxygen Reserve--A Pilot Study.

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From the Department of Anesthesiology and Pain Management, University of Texas Southwestern and Children's Medical Center, Dallas, Texas (P.S., J.W.S., P.N.O., R.P.P.); Outcomes Research Consortium, Cleveland, Ohio (P.S., J.W.S., D.I.S., T.E.); Department of Outcomes Research, Cleveland Clinic, Ohio (D.I.S.); and Department of Anesthesia, Edith Wolfson Medical Center, Tel Aviv University, Holon, Israel (T.E.).

Background: Pulse oximetry provides no indication of downward trends in PaO2 until saturation begins to decrease. The Oxygen Reserve Index (ORI) is a novel pulse oximeter-based nondimensional index that ranges from 1 to 0 as PaO2 decreases from about 200 to 80 mmHg and is measured by optically detecting changes in SvO2 after SaO2 saturates to the maximum. The authors tested the hypothesis that the ORI provides a clinically important warning of impending desaturation in pediatric patients during induction of anesthesia.

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