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Clinical correlations of serum anti-dsDNA immunoglobulin subfamilies in patients with systemic lupus erythematosus (SLE).
Autoimmunity
December 2025
Department of Clinical Immunology & Allergy, Westmead Hospital & ICPMR, Westmead, NSW, Australia.
Systemic lupus erythematosus (SLE) is an extremely heterogenous autoimmune disorder. A key biomarker, the double stranded (ds) DNA autoantibody, provides diagnostic specificity for SLE. We analyzed anti-dsDNA by mass spectrometry (MS) to determine if ascertaining the autoantibody's heavy chain variable region (IGHV) may hold any clinical relevance.
View Article and Find Full Text PDFSkin-iDISCO: An optimized tissue-clearing and labeling protocol for morphometric analysis of human cutaneous vasculature.
STAR Protoc
December 2024
University Bordeaux, Inserm, Bordeaux Institute of Oncology (BRIC), UMR 1312, F-33076 Bordeaux, France. Electronic address:
Tissue clearing enables deep imaging of long biological structures using light microscopy approaches. Protocols such as iDISCO are not currently available for human skin. Here, we present Skin-iDISCO, a tissue-clearing and labeling protocol for morphometric analysis of human cutaneous vasculature.
View Article and Find Full Text PDFCutaneous Immune Responses to Ablative Fractional Laser, Heat- and Cold-Based Dermatological Procedures.
Lasers Surg Med
December 2024
Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Objective: Physical treatment modalities, such as ablative fractional laser (AFL), electrocautery, and cryotherapy, are extensively used in the field of dermatology. This study aimed to characterize the short-term innate and adaptive immune responses induced by AFL compared with heat- and cold-based procedures.
Materials And Methods: Innate (CD11bLy6G neutrophils) and adaptive (CD8CD3 T cells) immune cell infiltration and histopathological changes were examined in murine skin on Days 1 and 7, following AFL, monopolar-electrocautery (RF), thermocautery, and cryotherapy.
The efficacy of a nitric oxide-releasing formulation on nares isolated Methicillin-Resistant in porcine wound infection model.
Front Cell Infect Microbiol
December 2024
Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Background: The colonization of (SA) acquired in nosocomial infections may develop acute and chronic infections such as Methicillin-Resistant (MRSA) in the nose. As a commensal microorganism with the ability to form a biofilm, SA can dwell on the skin, nostrils, throat, perineum, and axillae of healthy humans. Nitric oxide (NO) is an unstable gas with various molecular functions and has antimicrobial properties which are converted into many potential treatments.
View Article and Find Full Text PDFFungating mass on the breast of a male patient.
Dermatol Online J
October 2024
Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA.
Breast cancer is one of the most common malignancies that can lead to cutaneous metastasis. Dermatopathologists often play an important role in the diagnosis of breast cancer metastasis to the skin. Rarely, dermatopathologists render a histopathologic diagnosis of primary breast cancer.
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