In the mol-ecule of the title compound, [CdBr2(C14H12N2)(C2H6OS)], the Cd(II) atom is five-coordinated in a distorted trigonal-bipyramidal configuration by two N atoms from a 2,9-dimethyl-1,10-phenanthroline ligand, one O atom from a dimethyl sulfoxide ligand and two Br atoms. In the crystal, π-π contacts between the pyridine and benzene rings [centroid-centroid distances = 3.710 (5), 3.711 (6) and 3.627 (5) Å] stabilize the structure.
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http://dx.doi.org/10.1107/S1600536812050106 | DOI Listing |
J Appl Microbiol
March 2011
Department of Microbiology, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
Aims: Polysaccharide intercellular adhesin (PIA) is the main agglutination agent in the biofilm forming strain Staphylococcus epidermidis. To find an explanation for the observed inhibition of biofilm formation by allicin, we studied the effect of allicin on PIA production in samples treated with sub MIC doses of allicin and compared this with a control culture without allicin.
Methods And Results: Bacteria (Staph.
Cancer Biol Ther
July 2009
MCG Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.
Heat shock protein (hsp) 90 inhibitors promote proteasomal degradation of pro-growth and pro-survival hsp90 client proteins, including CDK4, c-RAF and AKT, and induce apoptosis of human lymphoma cells. The pan-histone deacetylase inhibitor vorinostat has also been shown to induce growth arrest and apoptosis of lymphoma cells. Here, we determined the effects of the more soluble, orally bio-available, geldanamycin analogue 17-NN-dimethyl ethylenediamine geldanamycin (DMAG, Kosan Biosciences Inc.
View Article and Find Full Text PDFGynecol Oncol
February 2005
Department of Obstetrics and Gynecology, University of Michigan Medical Center, Med. Sci. II, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0618, USA.
Objective: HSP90 is a cellular chaperone that is overexpressed in many cancers. HSP90 assists in proper folding of a variety of clients, many of which are oncoproteins. HSP90 has been shown to be elevated in endometrial, ovarian, and breast cancer.
View Article and Find Full Text PDFBiochem J
May 1994
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta 30332.
C-terminal alpha-amidation is a structural feature essential to the biological activity of many peptide hormones. Peptidylglycine alpha-amidating mono-oxygenase (PAM; EC 1.14.
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