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A Mixed Methods Study of Medication Adherence in Adults with Neurofibromatosis Type 1 (NF1) on a Clinical Trial of Selumetinib.
Cancers (Basel)
January 2025
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9030 Old Georgetown Road, Bethesda, MD 20892-8200, USA.
Background: Oral therapeutic options for plexiform neurofibromas (PNs) in individuals with neurofibromatosis type 1 (NF1) are receiving attention in clinical research. The MEK inhibitor (MEKi) Selumetinib is FDA-approved in children ages 2+ years with inoperable PNs, and shows activity in adults. Prolonged therapy with selumetinib is necessary to maintain tumor reduction.
View Article and Find Full Text PDFDisseminated histoplasmosis in a 4-month-old infant presenting with prolonged fever and pancytopenia: A case report.
J Mycol Med
January 2025
University of Illinois College of Medicine Peoria, Peoria, IL, USA; Children's Hospital of Illinois, Peoria, IL, USA. Electronic address:
Background: Histoplasmosis is the most prevalent endemic mycosis in the United States, typically affecting immunocompromised individuals. Diagnosis of histoplasmosis in immunocompetent patients is rare, particularly among young infants, with only a few cases reported.
Case Presentation: We present a 4-month-old female with a history of prematurity who initially presented with 11 days of fever.
Behavioral Intervention with Eye-Use Monitoring to Delay Myopia Onset and Progression in Children: A Cluster Randomized Trial.
Ophthalmology
January 2025
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Shandong Academy of Eye Disease Prevention and Therapy, Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Shandong Provincial Clinical Medical Research Center of Optometry and Children Visual Impairment Prevention and Control, Shandong Engineering Technology Research Center of Visual Intelligence, Shandong Institute of Children Health and Myopia Prevention and Control, Shandong, China; Shandong University of Traditional Chinese Medicine, Shandong, China; Ophthalmology & Optometry Medical School, Shandong University of Traditional Chinese Medicine, Shandong, China. Electronic address:
Purpose: To assess the efficacy of a behavioral intervention using Eye-Use Monitoring technology to delay the onset and progression of myopia in children.
Design: A prospective, cluster-randomized, parallel-groups, examiner-masked, clinical trial (Chinese Clinical Trial Registry, ChiCTR2100052101).
Participants: A total of 413 children from grades 2 to 4 in Shandong, China, from October 2021 to December 2023 were randomized by class into three groups: reminder & feedback (6 classes, 156 children), reminder-only (5 classes, 147 children), and control (3 classes, 110 children).
The effects of social loss and isolation on partner odor investigation and dopamine and oxytocin receptor expression in female prairie voles.
Neuropharmacology
January 2025
Neurosciences PhD Program, School of Pharmacy, University of Kansas, Lawrence, KS, United States; Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, United States. Electronic address:
In humans, grief is characterized by intense sadness, intrusive thoughts of the deceased, and intense longing for reunion with the deceased. Human fMRI studies show hyperactivity in emotional pain and motivational centers of the brain when an individual is reminded of a deceased attachment figure, but the molecular underpinnings of these changes in activity are unknown. Prairie voles (Microtus ochrogaster), which establish lifelong social bonds between breeding pairs, also display distress and motivational shifts during periods of prolonged social loss, providing a model to investigate these behavioral and molecular changes at a mechanistic level.
View Article and Find Full Text PDFProlonged grief symptoms and lingering attachment predict approach behavior toward the deceased.
J Trauma Stress
January 2025
Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, the Netherlands.
Following the death of a loved one, both approach behaviors related to the deceased (i.e., engagement with feelings, memories, and/or reminders of the deceased) and the avoidance of reminders of the death are theorized to precipitate severe and persistent grief reactions, termed prolonged grief.
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