The snakebite envenoming is an important medical emergency. The envenoming is a complex medical emergency involving the site of the bite as well as multiple organ system. The symptoms and signs depend on the type and amount of venom injected, location of bite, victims' age, body size and general health conditions. This study clarified the clinical presentations; factors involved in complications and the outcome in relation to timing of polyvalent snake antivenin administration in 50 Patients were selected from cases admitted to Al-Salam Hospital at Saadah, Republic of Yemen. The manifestations of envenoming and complications were recorded. Treated patients were analyzed to determine the factors involved in complications and the outcomes in relation to the timing of polyvalent snake antivenin administration The bitten patients had envenoming (80%), bitten at night (68%), while walking barefooted (84%), complaining from pain (76%) and limb swelling (56%). The systemic manifestations were common only in severe cases and patients attend to the hospital after six hours from snake bite. All patients had envenoming developed coagulation abnormalities. Two cases (4%) died from cerebral hemorrhage and multi organ failure.
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January 2025
Emergency Department, Setthatirath Hospital, Vientiane, Laos.
Snakebite envenoming in pregnant women is rare, accounting for approximately 0.5-1.8% of all snakebite cases.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
January 2025
Pharm-Biotechnology and Traditional Medicine Centre (PHARMBIOTRAC), Faculty of Medicine, Mbarara University of Science and Technology, Mbarara 40006, Uganda.
Snake venom, a complex mixture of proteins, has attracted human attention for centuries due to its associated mortality, morbidity and other therapeutic properties. In sub-Saharan Africa (SSA), where snakebites pose a significant health risk, understanding the genetic variability of snake venoms is crucial for developing effective antivenoms. The wide geographic distribution of venomous snake species in SSA countries demonstrates the need to develop specific and broad antivenoms.
View Article and Find Full Text PDFTrop Med Infect Dis
December 2024
Institut Pasteur Medical Center, Paris Cité University, F-75015 Paris, France.
Snakes responsible for bites are rarely identified, resulting in a loss of information about snakebites from venomous species whose venom effects are poorly understood. A prospective clinical study including patients bitten by a snake was conducted in Cameroon between 2019 and 2021 to evaluate the efficacy and tolerability of a marketed polyvalent antivenom. Clinical presentation during the first 3 days of hospitalization was recorded following a standardized protocol.
View Article and Find Full Text PDFToxins (Basel)
December 2024
Poison Control Center, The University of Arizona College of Pharmacy, Tucson, AZ 85724, USA.
The onset, progression, and severity of pain following rattlesnake envenomation are highly variable between patients. Pain can be severe and persistent, seemingly refractory to opioid analgesics. The ability of antivenom to directly relieve pain has not been well studied.
View Article and Find Full Text PDFCureus
November 2024
Community Medicine, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, IND.
Background Snakebite envenomation remains a significant public health challenge in tropical countries, particularly affecting the pediatric population. Children are especially vulnerable because of their smaller body mass, outdoor activities, and delayed presentation to healthcare facilities. This study aimed to analyze the clinical profile, demographic patterns, and envenomation characteristics of snakebites in children aged 1-16 years presenting to a tertiary care center.
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