AI Article Synopsis
- Rats were exposed to diesel exhaust particles (DEPs) for one to three months to test their toxicity on the bladder.
- In the three-month exposure group, higher doses of DEPs caused damage to bladder cell structures, increased lipid peroxidation, and reduced antioxidase enzyme activity.
- The findings suggest that DEPs are harmful to the bladder, likely due to oxidative stress from an imbalance between pro-oxidants and antioxidants.
Article Abstract
To determine whether diesel exhaust particles (DEPs) could be a toxic agent to the bladder, rats were exposed to different concentrations of DEPs for one month or three months. When the rats were sacrificed, morphologic changes of the urothelium were investigated. The antioxidase activity and the levels of lipid peroxidation in the bladder were assayed. In the three-month group, DEPs at doses of 21.03 μg/μl insulted the structural integrity of surface glycosaminoglycans, widened the gap between urothelial cells, increased levels of lipid peroxidation, and decreased antioxidase activities in the urinary bladder (p<0.05). Furthermore, DEPs at a dose of 5.61 μg/μl decreased glutathione, catalase, and glutathione peroxidase activities (p<0.05). These results led to the conclusion that DEPs were a toxic agent in the bladder. The toxic effects might be attributed to oxidative damage mediated by pro-oxidant/antioxidant imbalance or excessive free radicals.
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| http://dx.doi.org/10.1016/j.etap.2013.01.014 | DOI Listing |
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