AI Article Synopsis
- Understanding the spatial arrangement of mitochondrial proteins can improve our knowledge of how mitochondria work and their link to diseases.
- Most mitochondrial proteins lack information on their specific locations and roles in mitochondrial diseases.
- The study used a Mitochondrial Protein Functional (MPF) network to map these proteins' positions, revealing insights into their functions and potential disease-related genes.
Article Abstract
Characterizing the spatial organization of the human mitochondrial proteome will enhance our understanding of mitochondrial functions at the molecular level and provide key insight into protein-disease associations. However, the sub-organellar location and possible association with mitochondrial diseases are not annotated for most mitochondrial proteins. Here, we characterized the functional and spatial organization of mitochondrial proteins by assessing their position in the Mitochondrial Protein Functional (MPF) network. Network position was assigned to the MPF network and facilitated the determination of sub-organellar location and functional organization of mitochondrial proteins. Moreover, network position successfully identified candidate disease genes of several mitochondrial disorders. Thus, our data support the use of network position as a novel method to explore the molecular function and pathogenesis of mitochondrial proteins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590558 | PMC |
| http://dx.doi.org/10.1038/srep01403 | DOI Listing |
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