Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jss.2013.01.043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Erythropoiesis-stimulating agents for preventing acute kidney injury.
Cochrane Database Syst Rev
September 2024
Global Health Nursing, Graduate School of Nursing Science, St. Luke's International University, Tokyo, Japan.
Background: Acute kidney injury (AKI) is characterised by a rapid decline in kidney function and is caused by a variety of clinical conditions. The incidence of AKI in hospitalised adults is high. In animal studies, erythropoiesis-stimulating agents (ESA) have been shown to act as a novel nephroprotective agent against ischaemic, toxic, and septic AKI by inhibiting apoptosis, promoting cell proliferation, and inducing antioxidant and anti-inflammatory responses.
View Article and Find Full Text PDFErythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction.
Biomed Pharmacother
September 2023
Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education，Wenzhou Medical University, Zhejiang 325035, China; Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Zhejiang 325035, China. Electronic address:
Septic gut damage is critical in the progression of sepsis and multiple organ failure, characterized by gut microbiota dysbiosis and epithelium deficiency in the gut barrier. Recent studies highlight the protective effects of Erythropoietin (EPO) on multiple organs. The present study found that EPO treatment significantly alleviated the survival rate, suppressed inflammatory responses, and ameliorated intestine damage in mice with sepsis.
View Article and Find Full Text PDFPrognostic Value of HIF-1α-Induced Genes in Sepsis/Septic Shock.
Med Sci (Basel)
June 2023
1st Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece.
Hypoxia is characterized as one of the main consequences of sepsis, which is recognized as the leading cause of death in intensive care unit (ICU) patients. In this study, we aimed to examine whether the expression levels of genes regulated under hypoxia could be utilized as novel biomarkers for sepsis prognosis in ICU patients. Whole blood expression levels of hypoxia-inducible factor-1α (), interferon-stimulated gene 15 (), hexokinase 2 (), lactate dehydrogenase (), heme oxygenase-1 (), erythropoietin (), and the vascular endothelial growth factor A () were measured on ICU admission in 46 critically ill, initially non-septic patients.
View Article and Find Full Text PDFCyclic helix B peptide ameliorated the sepsis-induced injury in human HPMEC cells through regulating NF-κB.
Clin Immunol
December 2022
Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, No. 180, Fengling Rd, Shanghai 200032, PR China. Electronic address:
Background: Sepsis is a life-threatening condition. The incidence of severe sepsis is increasing. Sepsis is often complicated with organ dysfunctions.
View Article and Find Full Text PDFErythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection.
Front Immunol
August 2022
Institute of Immunology, Army Medical University, Chongqing, China.
Initial lipopolysaccharide (LPS) exposure leads to a hypo-responsive state by macrophages to a secondary stimulation of LPS, known as endotoxin tolerance. However, recent findings show that functions of endotoxin-tolerant macrophages are not completely suppressed, whereas they undergo a functional re-programming process with upregulation of a panel of molecules leading to enhanced protective functions including antimicrobial and tissue-remodeling activities. However, the underlying molecular mechanisms are still elusive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!