Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly malignant tumor that occurs in the nasal cavity and/or paranasal sinuses. Prognosis is poor despite multimodality treatment. Currently, there is no optimal standard of treatment, partially due to a lack of research defining the biology of such tumors. This report discusses two SNUC cases where patients received a novel chemotherapeutic approach using cisplatin, etoposide, Adriamycin (doxorubicin), metformin, and adjuvant melatonin therapies based on morphoproteomic-guidance, followed by consolidation with chemoradiation therapy. This resulted in excellent and objective tomographic and magnetic resonance imaging and clinical responses including complete responses in the induction phase utilizing morphoproteomic-guided therapies. Later, endoscopic excision of the tumor bed failed to reveal any residual tumor. Morphoproteomics helped to define the biology of these SNUC tumors and provided targets for the agents employed, creating a new treatment paradigm for such tumors. This treatment regimen poses a new effective regimen to treat SNUC.
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- A study analyzed sinonasal malignancies in Germany using data from the German Center for Cancer Registry, covering 8,332 cases from 2003 to 2015 to address gaps in cancer registries.
- The findings showed an increase in cancer incidence, particularly among men, with a five-year overall survival rate of 63% for nasal cavity cancers, but lower rates for those in the frontal sinus.
- The study highlighted the varying survival rates among different tumor types, emphasizing the need for improved early-stage screening due to the moderate to high mortality rates associated with sinonasal cancers, particularly for sinonasal undifferentiated carcinoma and mucosal melanoma.
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