AI Article Synopsis
- Anesthesiologists need to understand the specific goals of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion, along with the relevant chemotherapeutic drugs.
- Successful management during these procedures requires navigating complex physiological changes, such as hyperthermia, abdominal pressure, and changes in heart function.
- As these surgical techniques become more common, there is a need for more research to clarify the chemistry and effectiveness of treatment, which will guide better perioperative care.
Article Abstract
Anesthesiologists face several perioperative challenges when patients need cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion. To adequately care for these patients, anesthesiologists must understand the goals and objectives of the operation in addition to having a basic knowledge of the chemotherapeutic drugs that are frequently used. Optimal anesthetic management of patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion requires control of a complex interplay of physiologic mechanisms, including hyperthermia, abdominal hypertension, electrolyte abnormalities, coagulopathies, increased cardiac index, oxygen consumption, and decreased systemic vascular resistance. As this surgery continues to gain popularity among oncologic surgeons, further studies that clearly define the chemistry, pharmacokinetics, pharmacodynamics, and end points of efficacy need to be performed to elucidate optimal perioperative management.
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| http://dx.doi.org/10.1213/ANE.0b013e3182860fff | DOI Listing |
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