Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12664-013-0310-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Superficial angiomyxoma in the scrotum].
Medicina (B Aires)
December 2024
Servicio de Patología, Hospital Interzonal General de Agudos Gral. San Martín, La Plata, Buenos Aires, Argentina.
Superficial angiomyxoma is a benign neoplasm of mesenchymal origin that affects both sexes with a slight predilection for males. It can present in a solitary or multiple form, within the framework of the Carney complex, an autosomal dominant syndrome characterized by the triad: cutaneous and cardiac myxomas, skin pigmentation and endocrine overactivity. They occur more commonly in the head and neck, trunk and lower limbs; the location in the genital region and particularly in the scrotum is very unusual.
View Article and Find Full Text PDFPathologic diagnosis and molecular features of gastrointestinal stromal tumors: a mini-review.
Front Oncol
November 2024
Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Article Synopsis
- * About 80% of GISTs have mutations in KIT or PDGFRA that affect how they behave and respond to treatment; a special type called SDH-deficient GISTs is linked to certain genetic syndromes and presents different challenges.
- * The primary treatment involves surgery and the drug imatinib for advanced cases, but resistance to treatment is a major issue, particularly in kids and wildtype GISTs, highlighting the need for better therapies and personalized treatment approaches.
Gastrointestinal Stromal Tumors: Variants and Some Pitfalls That They Create.
Adv Anat Pathol
November 2024
Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL.
The diagnosis of gastrointestinal stromal tumors (GISTs) is generally straightforward using a combination of histologic evaluation and pertinent immunohistochemical staining with CD117/kit and DOG-1 (discovered on GIST) antibodies. However, this tumor can be challenging in cases with an unusual morphology, in limited biopsies, for those in uncommon sites, post-treatment, and when other neoplasms express CD117/kit and DOG-1, thereby mimicking GIST. Finding epithelioid GISTs in the stomach in younger patients should prompt testing for succinate dehydrogenase (SHD)-deficiency using immunohistochemical staining for subunit B (SDHB).
View Article and Find Full Text PDFGastrointestinal stromal tumours (GIST) in children: An update of this orphan disease.
Bull Cancer
October 2024
Pediatric Hematology Oncology Department, La Timone Children's Hospital, AP-HM, 264, rue St Pierre, 13385 Marseille cedex, France. Electronic address:
Article Synopsis
- - Gastrointestinal stromal tumours (GIST) are digestive tract tumors primarily affecting adults, with limited management guidelines for pediatric cases.
- - An updated literature review reveals that GIST in children often links to syndromic or familial contexts, with over 170 documented cases, primarily involving genetic alterations in Succinate Dehydrogenase (SDH).
- - Management recommendations for pediatric GIST are similar to those for adults, but specific biological differences necessitate tailored therapeutic approaches, prompting international collaborations to enhance understanding of this rare condition.
Gastrointestinal stromal tumor in Carney's triad with laparoscopic total gastrectomy: a case report.
Surg Case Rep
October 2024
Hyogo Amagasaki General Center, Amagasaki, Japan.
Article Synopsis
- Carney's triad is a rare syndrome featuring the presence of gastric gastrointestinal stromal tumors (GIST), pulmonary chondromas, and extra-adrenal paragangliomas, as illustrated by a case study of a 28-year-old woman.
- The patient was diagnosed with multiple gastric tumors and a lung nodule during a routine check-up, leading to a total gastrectomy after discovering metastasis in lymph nodes.
- Post-surgery, despite refusing adjuvant therapy, she has been disease-free for 2 years, highlighting the need for careful surgical intervention in similar cases.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!