AI Article Synopsis
- Pre-operative chemotherapy in patients undergoing major liver resection for colorectal metastases was found to significantly reduce the regeneration of liver volume compared to those who did not receive chemotherapy.
- A study involving 74 patients showed that liver volume regeneration was lower (83% vs. 91%) in those who underwent chemotherapy within three months before surgery.
- The timing of chemotherapy relative to surgery plays a crucial role, as a longer interval between the end of chemotherapy and resection is associated with better liver regeneration outcomes.
Article Abstract
Background: Chemotherapy before resection of colorectal metastases in the liver is extensively used and has been shown to induce histopathological changes in the liver parenchyma, although little is known about the effect of chemotherapy on liver regeneration. The aim of this study was to determine if pre-operative chemotherapy influences the regenerated liver volume after a major liver resection.
Patients And Methods: This retrospective cohort study included 74 patients subjected to a major liver resection for colorectal metastases. Patients were divided into two groups depending on whether they had been treated with chemotherapy less than 3 months before surgery or not. Liver volumes were measured before and 1 year after resection.
Results: Pre-operative chemotherapy reduced volumetric liver regeneration (83 ± 2% versus 91 ± 2%; P = 0.007) as compared with patients without chemotherapy. There was a linear correlation between regenerated volume and time interval between the end of chemotherapy to resection (P = 0.031).
Conclusions: Pre-operative chemotherapy in patients with colorectal liver metastases negatively affects volume regeneration after a partial hepatectomy. The time interval between chemotherapy and surgery determines the impact of these affects.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731588 | PMC |
| http://dx.doi.org/10.1111/hpb.12040 | DOI Listing |
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