Mass injury events present a unique medical challenge. Effective communications and coordination of resources including trained personnel as well as supplies and equipment are critical in these emergent situations. In the U.S., the availability of allograft skin plays a lifesaving role in treatment of burn injuries. Maintaining an adequate and readily available supply of this precious resource is critical for treatment of multiple injuries in the event of a national emergency. Allograft skin has historically been a local resource but contraction and consolidation of tissue banks has given rise to a small number of more nationally focused skin suppliers. While distinctly separate and essentially competing entities, these organizations come together in times of crisis to serve patients in need. Emergency preparations must include the ability to monitor and coordinate the capabilities of these organizations to supply lifesaving tissue grafts in times of national and global disasters.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10561-013-9367-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral health and rehabilitation in face transplant recipients - a systematic review.
Clin Oral Investig
January 2025
Department of Cranio- and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Article Synopsis
- Facial transplantation (FT) aids in severe facial defects by using complex tissues, making oral health crucial for successful outcomes, but there's limited research in this area.
- A systematic review identified 19 relevant studies out of nearly 7,000 articles, with most cases being male and originating from the U.S. and France, highlighting common oral issues like malocclusion.
- Routine oral health evaluations are vital for FT patients to avoid complications, but more high-quality research is necessary to set standardized care practices.
Clinical Implications of Skin Cancer in Kidney Transplant Recipients in the Era of Immune Checkpoint Inhibitors.
J Clin Med Res
December 2024
Nephrology, Southern Illinois Health, Carbondale, IL, USA.
Long-term survival has improved in kidney transplant recipients (KTRs) due to effective surgical techniques and anti-rejection therapies. Chronic immunosuppression associated with it has led to several types of skin cancers leading to substantial morbidity and mortality. Structured patient education including sun protective behaviors, regular dermatological surveillance, nicotinamide, long-chain omega-3 polyunsaturated fatty acids (PUFAs), early switch to mammalian target of rapamycin inhibitors (mTORis), combining them with low-dose calcineurin inhibitors (CNIs), can decrease the cancer risk.
View Article and Find Full Text PDFAn innovative ear transplantation for vascularized composite allotransplantation research in porcine model.
Sci Rep
December 2024
Pharmacology Research Group, Universidad del Valle, Colombia, Cali, 760043.
Vascularized composite allotransplantation (VCA) represents a clinical challenge for transplant therapy, as it involves different tissues with unique immunogenicity. Even when receiving immunosuppressive therapy, they are more vulnerable to severe hypoxia, microvascular damage, and ultimately the rejection or chronic graft dysfunction after transplantation. This study aimed to develop a surgical protocol for VCA of the ear in a porcine biomodel in the absence of immunosuppression, maintaining the in vitro co-culture of the allograft and assessing their relationship with allograft survival.
View Article and Find Full Text PDF26 Years of Skin Banking in Finland.
Eur Burn J
December 2024
Helsinki Burn Centre, Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, 00029 Helsinki, Finland.
Autologous skin grafts are the gold standard for definitive wound coverage in burn care, but allograft skin grafts are essential for providing temporary coverage in cases of extensive burns. The Helsinki Skin Bank, established in 1995 at the Helsinki Burn Centre, is Finland's only licensed skin bank, serving a population of 5.5 million.
View Article and Find Full Text PDFAdenosine triphosphate-mediated signaling of P2X7 receptors controls donor extracellular vesicle release and major histocompatibility complex cross-decoration after allotransplantation.
Am J Transplant
December 2024
Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
After skin allotransplantation, intercellular transfer of donor major histocompatibility complex molecules mediated primarily by extracellular vesicles (EVs) released by the allograft is known to contribute to semidirect and indirect activation of alloreactive T cells involved in graft rejection. At the same time, there is ample evidence showing that initiation of adaptive alloimmunity depends on early innate inflammation caused by tissue injury and subsequent activation of myeloid cells (macrophages and dendritic cells) recognizing danger-associated molecular patterns. Among these danger-associated molecular patterns, extracellular adenosine triphosphate plays a key role in innate inflammation by binding to P2X7 receptors (P2X7Rs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!