Purpose: The purpose of this study was to assess the predictability of sentinel lymph node biopsy (SNB) for oral squamous cell carcinoma (OSCC) when pathologic processing is performed without serial step sectioning.
Materials And Methods: We prospectively enrolled 36 patients with T1 or T2 cN0 OSCC into this institutional review board-approved prospective cohort study, and they underwent gamma probe-guided SNB in addition to selective neck dissection. The rate of patients with negative SNB results whose neck dissection was also negative for metastasis (negative predictive value) was the primary endpoint.
Results: Of the 28 patients whose sentinel lymph nodes were found to be pathologically and clinically node negative by routine hematoxylin-eosin stain and immunohistochemistry, 27 were found to have no other pathologically positive nodes, corresponding to a negative predictive value of 96%.
Conclusion: The results of this study suggest that SNB performed without the use of thin serial step sectioning may accurately predict neck stage in OSCC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.joms.2012.12.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Integrated Analysis of Cell-Free DNA and Novel Protein Biomarkers for Stratification and Therapy Monitoring in Stage IV Pancreatic Cancer: A Preliminary Study.
Diagnostics (Basel)
December 2024
Department of Medicine I (Hematology, Oncology and Stem Cell Transplantation), Freiburg University Medical Center, 79106 Freiburg, Germany.
Given the poor prognosis of metastatic pancreatic adenocarcinoma (mPDAC), closer disease monitoring through liquid biopsy, most frequently based on serial measurements of cell-free mutated ( cfDNA), has become a highly active research focus, aimed at improving patients' long-term outcomes. However, most of the available data show only a limited predictive and prognostic value of single-parameter-based methods. We hypothesized that a combined longitudinal analysis of cfDNA and novel protein biomarkers could improve risk stratification and molecular monitoring of patients with mPDAC.
View Article and Find Full Text PDFLittle evidence that nonmonogamous family structures are detrimental to children's well-being in Mpimbwe, Tanzania.
Proc Natl Acad Sci U S A
December 2024
Department of Human Behavior, Ecology and Culture, Max-Planck-Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Nuclear family structures are often thought to be essential for the well-being of children. Divorce, the loss of either biological parent, the presence of step-parents, and the practice of polygynous marriage have all been claimed to negatively impact child well-being. However, empirical research on these topics has been limited by the routine use of cross-regional and cross-sectional databases.
View Article and Find Full Text PDFEfficacy of Ultrasound-Guided Injection of Platelet-Rich Plasma in Treatment of Sports-Related Meniscal Injuries.
Indian J Radiol Imaging
January 2025
Department of Pathology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
Meniscal injuries are a common occurrence in sports-related activities, often leading to pain, reduced joint function, and impaired athletic performance. This study aimed to evaluate the role of ultrasound-guided intra-articular platelet-rich plasma (PRP)-rich fluid injection which was obtained through serial centrifugation in the treatment of meniscal injuries resulting from sports activities. A prospective study was conducted involving 54 cases with grade I, II, and III meniscal injuries, aged 18 and 43 years.
View Article and Find Full Text PDFThe Effects of Cognition and Vision While Walking in Younger and Older Adults.
Sensors (Basel)
December 2024
Department of Physical Therapy, California State University Long Beach, Long Beach, CA 90840, USA.
This study investigated how various cognitive tasks and visual challenges affect dual-task walking costs (DTWC) in younger and older adults. Twenty younger adults (Mean = 22.25, SD = 3.
View Article and Find Full Text PDF"It's Kind of a Rite of Passage": An Exploration Into Residents' Experience of Learning in a Critical Care Setting.
J Grad Med Educ
December 2024
is Associate Professor, Division of Pediatric Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Many trainees complete rotations in intensive care units (ICUs), but little is known about how ICU rotations impact learners. Understanding residents' experiences in ICU rotations is a crucial step toward improving resident education and understanding the consequences, intended and unintended, of critical care learning. We performed a qualitative study to understand how pediatric and emergency medicine residents experience a pediatric ICU (PICU) rotation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!