AI Article Synopsis
- Aminopeptidase N (APN/CD13) is overexpressed in tumor cells and is important for tumor spread and blood vessel formation.
- Researchers designed and tested new compounds based on leucine ureido derivatives to inhibit APN/CD13.
- Among these compounds, 8c was the most effective inhibitor, showing an IC50 value of 0.06 ± 0.041 μM, making it a candidate for further cancer treatment studies.
Article Abstract
Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC50 value to 0.06 ± 0.041 μM, which could be used for further anticancer agent research.
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| http://dx.doi.org/10.1016/j.bmc.2013.01.068 | DOI Listing |
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