AI Article Synopsis
Article Abstract
A series of thiazole bearing thiazolidin-4-one was discovered via high-throughput screening as non-competitive inhibitors of ADAMTS-5. Compound 31 appeared to give the best ADAMTS-5 inhibition and good selectivity over other metalloproteases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2013.01.121 | DOI Listing |
Publication Analysis
Top Keywords
series thiazole
8
bearing thiazolidin-4-one
8
thiazole derivatives
4
derivatives bearing
4
thiazolidin-4-one non-competitive
4
non-competitive adamts-5
4
adamts-5 aggrecanase-2
4
aggrecanase-2 inhibitors
4
inhibitors series
4
thiazole bearing
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!