Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580377 | PMC |
| http://dx.doi.org/10.4103/0970-0358.105996 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Curcuminoids, known for their antibacterial, anti-inflammatory, and wound healing properties, face challenges in medical applications due to their limited water solubility, resulting in poor bioavailability and clinical efficacy. This study introduces a novel approach to formulating 3D printing ink for personalized wound dressings by utilizing hydrophobic deep eutectic solvents (HDES) to incorporate poorly water-soluble compounds from (, curcuminoids and ar-turmerone) into hydrogels. The use of HDES, comprising either acetic acid or octanoic acid combined with menthol in a 2 : 1 molar ratio, significantly improved the solubility of curcuminoid derivatives and ar-turmerone by approximately 10 to 600 times, depending on the intrinsic chemical polarities of each compound, compared to conventional extraction solvents (, ethanol and water).
View Article and Find Full Text PDFUltrarapid-Acting Microneedles for Immediate Delivery of Biotherapeutics.
Adv Mater
November 2023
Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Subcutaneous (SC) injection is a common administration route for rapid and efficient delivery of biotherapeutics. However, syringe-based injections usually require professional assistance and are associated with pain and potential risks of infections, thus leading to undesired patient compliance and poor life quality. Herein, this work presents an ultrarapid-acting microneedle (URA-MN) patch for immediate transdermal delivery of therapeutics in a minimally invasive manner.
View Article and Find Full Text PDFAnalysis of flow rate and pressure in syringe-based wound irrigation using Bernoulli's equation.
Sci Rep
September 2022
College of Nursing Science, Kyung Hee University, Seoul, Republic of Korea.
The objective of this study was to examine the dependence of the pressure level in the wound area on the height of the syringe needle from the wound, the gauge of the needle, and the flow rate using the Bernoulli equation. This study was the control-volume analysis using the Bernoulli equation. At a given height of the syringe needle from the wound, the gauge of the syringe needle was fixed, and the pressure in the wound area, which depended on the flow rate of the irrigation solution discharged from the tip of the needle, was calculated according to the Bernoulli equation and the definition of the flow rate.
View Article and Find Full Text PDF3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System.
Pharmaceutics
October 2021
BIOMAT Research Group, Escuela de Ingeniería de Gipuzkoa, University of the Basque Country (UPV/EHU), Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain.
Native collagen doughs were processed using a syringe-based extrusion 3D printer to obtain collagen scaffolds. Before processing, the rheological properties of the doughs were analyzed to determine the optimal 3D printing conditions. Samples showed a high shear-thinning behavior, reported beneficial in the 3D printing process.
View Article and Find Full Text PDFPressures of Wilderness Improvised Wound Irrigation Techniques: How Do They Compare?
Wilderness Environ Med
December 2016
University of California San Francisco Fresno, Fresno, CA (Drs Luck, Campagne, and Spano). Electronic address:
Objective: Compare the pressures measured by improvised irrigation techniques to a commercial device and to prior reports.
Methods: Devices tested included a commercial 500-mL compressible plastic bottle with splash guard, a 10-mL syringe, a 10-mL syringe with a 14-ga angiocatheter (with needle removed), a 50-mL Sawyer syringe, a plastic bag punctured with a 14-ga needle, a plastic bottle with cap punctured by a 14-ga needle, a plastic bottle with sports top, and a bladder-style hydration system. Each device was leveled on a support, manually compressed, and aimed toward a piece of glass.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!