Int J Pept Protein Res
Laboratory of Peptide Chemistry, Academy of Sciences of the USSR, Pushchino, Moscow Region.
Published: April 1990
Peptide synthesis catalysed by papain was studied using thio-alpha-amino acids (S-acids) as a carboxyl component. It was found, for example, that with Z-AlaSH (pK 2.70) the maximal yield of the peptide Z-AlaValNH2 was obtained at pH 8-8.5. A two-fold excess of Z-AlaSH furnished peptides with yields close to 100%. Thio-amino acids with bulky side groups, for example, Z-IleSH, Z-Asp(OBu')SH, gave peptides with a low yield. Papain interacts with Z-AlaSH better than do bromelain or ficin.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/j.1399-3011.1990.tb00060.x | DOI Listing |
Chem Commun (Camb)
May 2012
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
Non-naturally enantioenriched cis-β-thio-α-amino acid derivatives were synthesized through one pot, cascade thio-Michael/ring opening reaction of aromatic thiols with (Z)-olefinic azlactones in good yields with high levels of diastereoselectivities and enantioselectivities, which was catalyzed by a chiral bifunctional thiourea-tertiary amine catalyst.
View Article and Find Full Text PDFProteins
June 2011
Departament d'Enginyeria Química, ETS d'Enginyeria Industrial de Barcelona, Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Spain.
Recently, we reported a database (Noncoded Amino acids Database; http://recerca.upc.edu/imem/index.
View Article and Find Full Text PDFBiochemistry
March 2004
Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Int J Pept Protein Res
April 1990
Laboratory of Peptide Chemistry, Academy of Sciences of the USSR, Pushchino, Moscow Region.
Peptide synthesis catalysed by papain was studied using thio-alpha-amino acids (S-acids) as a carboxyl component. It was found, for example, that with Z-AlaSH (pK 2.70) the maximal yield of the peptide Z-AlaValNH2 was obtained at pH 8-8.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.