AI Article Synopsis
- HCoV-EMC is linked to severe pneumonia and has similarities to SARS-CoV in how it infects human airway cells.
- It prevents the activation of the antiviral response mediated by IRF-3, which normally leads to production of interferons.
- However, HCoV-EMC is more vulnerable to the antiviral effects of interferons compared to SARS-CoV.
Article Abstract
Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624328 | PMC |
| http://dx.doi.org/10.1128/JVI.03496-12 | DOI Listing |
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