AI Article Synopsis
- The study investigates the role of the epigenetic regulator Brg1 in ureter development, finding that it is essential for the expression of key genes like p63, Pparγ, and sonic hedgehog (Shh) in ureteral epithelium.
- Brg1 is crucial for maintaining basal cell populations and guiding the terminal differentiation of umbrella cells, which are important for ureter function.
- When Brg1 is absent, it leads to a failure in Shh expression, causing impaired smooth muscle cell development and hydroureter, highlighting Brg1's central role in ureter development.
Article Abstract
Developing and adult ureters express the epigenetic regulator Brg1, but the role of Brg1 in ureter development is not well understood. We conditionally ablated Brg1 in the developing ureter using Hoxb7-Cre and found that Brg1 expression is upstream of p63, Pparγ, and sonic hedgehog (Shh) expression in the ureteral epithelium. In addition, epithelial stratification in the basal cells required Brg1-dependent p63 expression, whereas terminal differentiation of the umbrella cells required Brg1-dependent Pparγ expression. Furthermore, the loss of ureteric Brg1 resulted in failure of Shh expression, which correlated with reduced smooth muscle cell development and hydroureter. Taken together, we conclude that Brg1 expression unifies three aspects of ureter development: maintenance of the basal cell population, guidance for terminal differentiation of urothelial cells, and proper investment of ureteral smooth muscle cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609140 | PMC |
| http://dx.doi.org/10.1681/ASN.2012090902 | DOI Listing |
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