AI Article Synopsis
- The study investigates the relationship between the ALOX5 gene and susceptibility to tuberculosis (TB) in children from northern China.
- The research involved a case-control study with 488 pediatric participants, analyzing specific genetic variations (SNPs) using advanced genotyping techniques.
- Findings indicate that the T allele of the rs2115819 variant in the ALOX5 gene is linked to an increased risk of developing pediatric TB.
Article Abstract
Background: Genetic factors are involved in the etiology of Mycobacterium tuberculosis infection. Recently, ALOX5 has been identified as a candidate gene for tuberculosis (TB) susceptibility. We investigated whether an association between ALOX5 and TB exists in a Chinese pediatric population from northern China.
Methods: We conducted a case-control study comprising 488 individuals aged 2 months to 17 years by genotyping 18 tag-single-nucleotide polymorphisms (SNPs) from the ALOX5 gene. The tag-SNPs were selected from the international HapMap project. An Illumina BeadXpress Scanner was utilized for genotyping, supported by the high-density BeadArray technology in combination with an allele-specific extension, adapter ligation, and amplification assay. Statistical analyses were performed to determine correlations between genetic variation and disease.
Results: Our study is the first to show that ALOX5 is associated with susceptibility to pediatric TB in a subset of children in northern China. The rs2115819 T allele of ALOX5 presents a risk factor for childhood TB disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609609 | PMC |
| http://dx.doi.org/10.1089/gtmb.2012.0426 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioinformatic analysis of ferroptosis related biomarkers and potential therapeutic targets in vitiligo.
Sci Rep
January 2025
Department of Dermatology, Suining Central Hospital, No. 127, Western Desheng Road, Suining, 629000, People's Republic of China.
Vitiligo is a complex autoimmune skin disorder characterized by depigmentation and immune dysregulation. To elucidate the role of ferroptosis-related genes (FRGs) in vitiligo, we conducted a comprehensive analysis of gene expression data from the GSE53146 and GSE65127 datasets obtained from the GEO database. We identified 31 differentially expressed FRGs (DE-FRGs), with 21 genes upregulated and 10 downregulated.
View Article and Find Full Text PDFM2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps.
Clin Transl Allergy
December 2024
Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Background: Molecular signatures of chronic rhinosinusitis with nasal polyps (CRSwNP) related to macrophages remain unclear. This study aimed to develop a macrophage-associated diagnostic signature for CRSwNP.
Methods: Transcriptome data from 54 patients with CRSwNP and 37 healthy controls across GSE136825, GSE36830, and GSE72713 were used to identify differentially expressed genes (DEGs) between two groups.
Identification of lipid metabolism-related biomarkers and prognostic analysis in geriatric patients with sepsis.
J Infect Dev Ctries
October 2024
Cardiovascular Institute, Southeast University, Nanjing, China.
Introduction: This study aimed to find the lipid metabolism-associated biomarkers in geriatric patients with sepsis.
Methodology: The gene expression profiles of specimens from geriatric patients with sepsis were retrieved from the Gene Expression Omnibus database. Differentially expressed genes were obtained via "limma" R package, and modules and genes highly associated with geriatric patients with sepsis were screened via "WGCNA" R package.
Identification of CAPG as a potential prognostic biomarker associated with immune cell infiltration and ferroptosis in uterine corpus endometrial carcinoma.
Front Endocrinol (Lausanne)
November 2024
Shanghai-Ministry of Science and Technology Key Laboratory of Health and Disease Genomics, National Health Commission Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, School of Pharmacy, Fudan University, Shanghai, China.
Article Synopsis
- CAPG is a promising target for cancer therapy, especially in uterine corpus endometrial carcinoma (UCEC), but its role in immune response and prognosis requires further study.
- Research involving public databases showed that higher CAPG expression correlates with poorer survival rates and is linked to immune pathways and tumor microenvironment effects.
- Experiments revealed CAPG influences cell growth and mobility, affects ferroptosis markers, and its silencing enhances immune-related gene expression; several chemotherapy drugs were found to be effective for UCEC treatment.
Integrated systems pharmacology, molecular docking, and MD simulations investigation elucidating the therapeutic mechanisms of BHD in Alzheimer's disease treatment.
Metab Brain Dis
November 2024
Department of Biotechnology, National Institute of Technology, Andhra Pradesh, 534101, India.
Alzheimer's disease (AD) poses a longstanding health challenge, prompting a century-long exploration into its etiology and progression. Despite significant advancements in medical science, current AD treatments provide only symptomatic relief, urging a shift towards innovative paradigms. This study, departing from the amyloid hypothesis, integrates Systems Pharmacology, Molecular Docking and Molecular Dynamic Simulations to investigate a polyherbal phytoformulation (US 7,273,626 B2) rooted in Ayurveda for AD, consisting of Bacopa monnieri, Hippophae rhamnoides, and Dioscorea bulbifera (BHD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!