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| http://dx.doi.org/10.5698/1535-7511-12.6.216 | DOI Listing |
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Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy.
Neurobiol Pain
December 2024
Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients experiencing a painful and burning sensation in their extremities. Existing treatments provide limited relief without addressing the underlying mechanisms of the disease. PDN involves the gradual degeneration of nerve fibers in the skin.
View Article and Find Full Text PDFRibosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis.
Cell Rep
January 2025
Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:
Growing evidence suggests that ribosomes selectively regulate translation of specific mRNA subsets. Here, quantitative proteomics and cryoelectron microscopy demonstrate that poxvirus infection does not alter ribosomal subunit protein (RP) composition but skews 40S rotation states and displaces the 40S head domain. Genetic knockout screens employing metabolic assays and a dual-reporter virus further identified two RPs that selectively regulate non-canonical translation of late poxvirus mRNAs, which contain unusual 5' poly(A) leaders: receptor of activated C kinase 1 (RACK1) and RPLP2.
View Article and Find Full Text PDFA simple and efficient "cell in situ collagen zymography" technique to evaluate cellular collagenase activities in thyroid cancer cell lines.
Mol Biol Rep
December 2024
Department of Medical Biochemistry, School of Medicine, Dokuz Eylul University, Izmir, 35340, Türkiye.
Article Synopsis
- Collagenases, a type of matrix metalloproteinase, are key in cancer invasion and metastasis, but traditional analysis methods struggle with accurately measuring their activity in vitro.
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Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans.
Nat Commun
November 2024
Can Sucak Research Laboratory for Translational Immunology, Hacettepe University, Ankara, Türkiye.
IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the importance of the kinase function of IKKα in human physiology remains unknown since no biallelic variants disrupting its kinase activity have been reported. In this study, we present a homozygous germline missense variant in the kinase domain of IKKα, which is present in three children from two Turkish families.
View Article and Find Full Text PDFConvergent olfactory circuits for courtship in revealed by -Tango.
bioRxiv
October 2024
Department of Neuroscience, Brown University, Providence, RI, USA.
Animals exhibit sex-specific behaviors that are governed by sexually dimorphic circuits. One such behavior in male , courtship, is regulated by various sensory modalities, including olfaction. Here, we reveal how sexually dimorphic olfactory pathways in male flies converge at the third-order, onto lateral horn output neurons, to regulate courtship.
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