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Nanoparticle innovations in targeted cancer therapy: advancements in antibody-drug conjugates.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Antibody-drug conjugates (ADCs) have emerged as a promising strategy in targeted cancer therapy, enabling the precise delivery of cytotoxic agents to tumor sites while minimizing systemic toxicity. However, traditional ADCs face significant limitations, including restricted drug loading capacity, where an optimal drug-to-antibody ratio (DAR) is crucial; low DARs may lead to insufficient potency, while high DARs can cause rapid clearance and increased toxicity. Additionally, ADCs often suffer from instability in circulation due to the potential for premature release of cytotoxic agents, resulting in off-target effects and reduced therapeutic efficacy.
View Article and Find Full Text PDFHigh-Q Emission from Colloidal Quantum Dots Embedded in Polymer Quasi-BIC Metasurfaces.
Nano Lett
January 2025
Department of Electrical and Computer Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Metasurfaces supporting narrowband resonances are of significant interest in photonics for molecular sensing, quantum light source engineering, and nonlinear photonics. However, many device architectures rely on large refractive index dielectric materials and lengthy fabrication processes. In this work, we demonstrate quasi-bound states in the continuum (quasi-BICs) using a polymer metasurface exhibiting experimental quality factors of 305 at visible wavelengths.
View Article and Find Full Text PDFThe Effect of Polyethylene Fiber and Flowable Resin Composite on Fracture Resistance in the Restoration of Large MOD Cavities.
J Esthet Restor Dent
January 2025
Department of Restorative Dentistry, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Türkiye.
Objective: This in vitro study aims to evaluate the effect of placing polyethylene fibers used in large Class II MOD (mesio-occlusion-distal) cavities into different flowable resin composites and in different positions on the fracture resistance of the restoration.
Materials And Methods: Ninety healthy human molars were used in the study. No treatment was performed on 10 of these teeth and they were used as the control group.
Pre-exposure of abundant species to disturbance improves resilience in microbial metacommunities.
Nat Ecol Evol
January 2025
Department of Biology, University of Turku, Turku, Finland.
Understanding factors influencing community resilience to disturbance is critical for mitigating harm at various scales, including harm from medication to gut microbiota and harm from human activity to global biodiversity, yet there is a lack of data from large-scale controlled experiments. Factors expected to boost resilience include prior exposure to the same disturbance and dispersal from undisturbed patches. Here we set up an in vitro system to test the effect of disturbance pre-exposure and dispersal represented by community mixing.
View Article and Find Full Text PDFRecombinant Expression of a New Antimicrobial Peptide Composed of hBD-3 and hBD-4 in Escherichia coli and Investigation of Its Activity Against Multidrug-Resistant Bacteria.
Probiotics Antimicrob Proteins
January 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, No. 20 Dongda Street, Beijing, 100071, Fengtai District, China.
Human β-defensin (HBD) has been recognized as a promising antimicrobial agent due to its broad-spectrum antimicrobial activity against various pathogens. In our previous work, we engineered a chimeric human β-defensin, designated H4, by fusing human β-defensin 3 and human β-defensin 4, resulting in enhanced antimicrobial activity and salt stability. However, the high cost of chemical synthesis due to the relatively large number of amino acids in H4 has limited its applications.
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