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CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.
Proc Natl Acad Sci U S A
January 2025
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and TAPBPR promote the selection of immunogenic antigens from a large pool of intracellular peptides. Interactions of chaperoned MHC-I molecules with incoming peptides are transient in nature, and as a result, the precise antigen proofreading mechanism remains elusive.
View Article and Find Full Text PDFThe need to (climate) adapt: perceptions of German sports event planners on the imperative to address climate change.
Front Sports Act Living
December 2024
Faculty of Business Management & Social Sciences, Hochschule Osnabrück, University of Applied Sciences, Osnabrück, Germany.
Introduction: While the impact of anthropogenic climate change on sports and the subsequent need for adaptation to evolving climatic conditions are acknowledged, there remains a notable paucity of scientific inquiry within the realm of sports and sports event studies specifically addressing climate change and its ramifications for event planning and management. Existing studies predominantly stem from health, medical, weather and climate science and mostly focus on mega-events and elite athlete contexts. Moreover, they often only focus on one specific impact (e.
View Article and Find Full Text PDFEnhancing muscle and brain resilience: The role of prehabilitative exercise in mitigating disuse effects.
J Physiol
January 2025
Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Short-term disuse leads to rapid declines in muscle mass and strength. These declines are driven by changes at all levels of the neuromuscular system; the brain, spinal cord and skeletal muscle. In addition to neural input from the central and peripheral nervous systems to the muscle, molecular factors originating in the muscle can be transported to the central nervous system.
View Article and Find Full Text PDFIs there a relationship between psychiatrist's clinical assessment of medication non-adherence and treatment outcomes? Implications for practice.
BMC Psychiatry
December 2024
John George Psychiatric Hospital, 2060, Fairmont Drive, San Leandro, CA, 94578, USA.
Background: There is considerable research on the ramifications of medication non-adherence for adults with psychotic illnesses. Much of which has tightly controlled designs and strict inclusion/exclusion procedures (i.e.
View Article and Find Full Text PDFCells in the Polyaneuploid Cancer Cell State are Pro-Metastatic.
Mol Cancer Res
December 2024
Johns Hopkins University, Baltimore, MD, United States.
Article Synopsis
- The research investigates how prostate cancer adapts to changing environments and the role of the Polyaneuploid Cancer Cell (PACC) state in metastasis, suggesting that PACC can enhance metastatic potential.
- Evidence from previous studies shows that the presence of PACC in patient tumors correlates with a higher risk of future metastasis, prompting the use of innovative methods to analyze circulating and disseminated tumor cells from animal models.
- The findings reveal that a significant majority of these tumor cells were in the PACC state, and specific traits associated with PACC contribute to its ability to spread and colonize new sites, raising concerns about the effectiveness of certain cancer treatments that may inadvertently promote metastasis.
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