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Comparative study of permeation effects between vibrating microneedle and low-frequency sonophoresis systems.
Drug Deliv Transl Res
November 2024
College of Pharmacy, Hangzhou Medical College, Hangzhou, 310014, China.
Article Synopsis
- Microneedles and low-frequency ultrasound are two methods used to enhance drug penetration through the skin, and this study compares their effectiveness using the drug tetramethylpyrazine hydrochloride (TMPH).
- In laboratory experiments with rat skin, results showed that vibrating microneedles significantly increased TMPH permeability, achieving up to a 41.92-fold increase with optimal settings.
- Although low-frequency ultrasound also enhanced TMPH penetration, it only produced a 4.34-fold increase under specific conditions, indicating that vibrating microneedles are the more effective method for transdermal drug delivery.
Platelet rich plasma therapy versus other modalities for treatment of plantar fasciitis: A systematic review and meta-analysis.
Foot Ankle Surg
June 2024
Department of Orthopaedics and Rehabilitation, Yale University, New Haven, CT 06510, USA.
Article Synopsis
- Plantar fasciitis (PF) is a common cause of heel pain in adults, and treatments like platelet rich plasma (PRP) injections have shown effectiveness in managing PF alongside other non-surgical options.
- The study aimed to evaluate the effectiveness of PRP compared to various conservative treatments through a systematic review of randomized control trials (RCTs).
- The meta-analysis of 21 RCTs with 1356 patients found that PRP significantly outperformed treatments like extracorporeal shock wave therapy and corticosteroid injections in reducing pain scores, while showing the greatest improvement in function compared to phonophoresis.
Prolotherapy Versus Phonophoresis and Corticosteroid Injections for the Treatment of Plantar Fasciitis: A Randomized, Double-Blind Clinical Trial.
J Foot Ankle Surg
May 2024
Department of Physical Medicine and Rehabilitation, Yozgat City Hospital, Yozgat, Turkey.
The aim of this study was to compare the effectiveness of prolotherapy with phonophoresis and steroid injection in patients with plantar fasciitis (PF). One hundred forty-six patients with PF were randomly divided into prolotherapy, phonophoresis, and injection groups. The treatment method to be applied to them was determined by drawing lots of equal numbers of papers with "Prolotherapy," "Corticosteroid," and "Phonophoress" written on it among those who accepted to be treated.
View Article and Find Full Text PDFEffect of Zingiber Cassumunar Roxb. Phonophoresis Versus Aqua Sonic Gel on Pain, Range of Motion, and Functional Disability in Patients With Osteoarthritis of Knee: A Randomized Controlled Trial.
Cureus
December 2022
Musculoskeletal Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
The aim of this trial was to collate, analyze, and compare the effectiveness of phonophoresis and ultrasound adjunct to Otago exercise program for pain, knee range of motion, and functional disability in patients with grades I and II of knee osteoarthritis. This is a single-blind randomized control study. A total of 52 patients with pre-diagnosed osteoarthritis on radiological investigation were included in the study.
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