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Intranasal antivirals against respiratory syncytial virus: the current therapeutic development landscape.
Expert Rev Anti Infect Ther
August 2024
Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Article Synopsis
- Respiratory syncytial virus (RSV) primarily impacts vulnerable populations, leading to bronchiolitis and respiratory problems, yet effective antivirals have been challenging to develop despite recent RSV vaccine approvals.
- The newly approved nirsevimab shows promise for use as a prophylactic treatment, while current therapeutics are often delivered via IV or IM rather than more convenient IN methods.
- Research is increasingly focusing on intranasal (IN) antiviral therapies to target RSV directly in the respiratory tract, aiming to lessen illness severity and halt the spread of the virus more effectively.
Clinico-Virological Outcomes and Mutational Profile of SARS-CoV-2 in Adults Treated with Ribavirin Aerosol for COVID-19 Pneumonia.
Microorganisms
June 2024
Laboratory of Microbiology and Virology, IRCCS San Raffaele Hospital, 20132 Milan, Italy.
The emergence of new SARS-CoV-2 variants can affect vaccine efficacy, laboratory diagnosis and the therapies already available, triggering interest in the search for antiviral agents for SARS-CoV-2 infections. Ribavirin (RBV) is a broad-spectrum antiviral with demonstrated in vitro activity against multiple viruses, including SARS-CoV-2. This retrospective study evaluated the dynamics and viral clearance of SARS-CoV-2 in hospitalised adult participants (PTs) with COVID-19 pneumonia who received an RBV aerosol within a compassionate use study.
View Article and Find Full Text PDFPolyethylene Glycol-Modified Cationic Liposome as a Promising Nano Spray for Acute Pneumonia Treatment.
Polymers (Basel)
May 2024
Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Acute pneumonia (AP), triggered primarily by pathogens like bacteria and viruses, is a leading cause of human mortality. Ribavirin, a broad-spectrum antiviral agent, plays a pivotal role in the treatment of AP. However, its therapeutic use is hindered by the need for high dosages and the associated cardiac and hepatic toxicities.
View Article and Find Full Text PDF[Clinical comprehensive evaluation of Houyanqing Oral Liquid in treatment of acute pharyngitis].
Zhongguo Zhong Yao Za Zhi
January 2024
Institute of Basic Medicine in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
This study systematically combed the existing evidence of Houyanqing Oral Liquid in the treatment of acute pharyngitis from the "6+1" dimensions of safety, effectiveness, economy, innovation, suitability, accessibility, and characteristics of traditional Chinese medicine(TCM) and carried out qualitative and quantitative analysis of the data from each dimension. The multi-criteria decision analysis(MCDA) model and CSC v2.0 were used to evaluate the clinical value of this drug, so as to provide evidence for the selection of essential drugs in the department of otolaryngology and for medical and health decision-making.
View Article and Find Full Text PDFCombined intravenous ribavirin and recombinant human interferon α1b aerosol inhalation for adenovirus pneumonia with plastic bronchitis in children: a case report and review of literature.
Front Pediatr
February 2024
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Background: Human adenovirus (HAdV) infections in children can lead to profound pulmonary injury and are frequently associated with severe complications, particularly in cases concomitant with plastic bronchitis. Managing this condition presents significant challenges and carries an exceptionally high fatality rate. Regrettably, there are currently no specific antiviral agents that have demonstrated efficacy in treating severe adenovirus pneumonia in children.
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