Aims: Several reports have suggested that nitrates limit acute ischaemic damage by a mechanism similar to preconditioning. This study aims to evaluate the effect of chronic oral nitrates on the clinical presentation and short-term outcomes of patients admitted with acute coronary syndrome (ACS).
Methods: A retrospective cohort study was conducted in patients with ACS admitted to 62 acute care units from 2010 to 2011. A propensity score-matched samples analysis was performed.
Results: We analysed 3171 consecutive patients, of whom 298 (9.4%) were chronically treated with nitrates. Patients previously treated with nitrates had higher comorbidity and disease severity at admission, lower prevalence of ACS with ST elevation, lower troponin elevation, higher prevalence of initial Killip class 2-4 and higher hospital mortality. The propensity score-matched analysis confirmed that previous use of nitrates is independently associated with a lower prevalence of ST-elevation ACS [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.36-0.78; P = 0.0014] and a lower troponin elevation (OR 0.61, 95% CI 0.41-0.92) but not with Killip class on admission (OR 1.18, 95% CI 0.83-1.67, P = 0.3697) or mortality (OR 0.71, 95% CI 0.37-1.38, P = 0.3196).
Conclusion: The results support the hypothesis that nitrates have a protective effect on acute ischaemic injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2459/JCM.0b013e32835f4df1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Promoting defect formation and inhibiting hydrogen evolution by S-doping NiFe layered double hydroxide for electrocatalytic reduction of nitrate to ammonia.
Water Res
December 2024
Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address:
Activation of HO cleavage for H* production by defect engineering eliminates the insufficient supply of protons in the NORR process under neutral conditions. However, it remains challenging to precisely control the defect formation for optimizing the equilibrium between H* production and H* binding. Here, we propose a strategy to boost defect generation through S-doping induced NiFe-LDH lattice distortion, and successfully optimize the balance of H* production and binding.
View Article and Find Full Text PDFAssessing the efficacy of synthetic compounds foliar sprays in alleviating terminal heat stress in late-sown wheat ().
Funct Plant Biol
January 2025
Krishi Vigyan Kendra, Siwan, Dr. RPCAU, Pusa, Bihar, India.
Detrimental effects of terminal heat stress could be mitigated by exogenous application of synthetic compounds by preserving cell membrane integrity and protecting against oxidative damage. A field experiment was conducted to test the application of seven synthetic compounds on wheat growth traits: (1) thiourea (20 mM and 40mM); (2) potassium nitrate (1% and 2%); (3) sodium nitroprusside (400 μg mL-1 and 800μg mL-1 ); (4) dithiothreitol (25 ppm and 50ppm); (5) salicylic acid (100 ppm and 200ppm); (6) thioglycolic acid (200 ppm and 500ppm); and (7) putrescine (4 mM and 6mM). These compounds were applied at the anthesis and grain-filling stages to enhance physio-biochemical traits and yield attributes of wheat (Triticum aestivum ) cvs GW-11 and GW-496 under terminal heat stress.
View Article and Find Full Text PDFGenerating Strong Metal-Support Interaction and Oxygen Vacancies in Cu/MgAlO Catalysts by CO Treatment for Enhanced CO Hydrogenation to Methanol.
ACS Appl Mater Interfaces
January 2025
Department of Chemical Engineering, and Guangdong Provincial Key Laboratory of Materials and Technologies for Energy Conversion (MATEC), Guangdong Technion Israel Institute of Technology (GTIIT), Guangdong 515063, China.
Strong metal-support interactions (SMSIs) are essential for optimizing the performance of supported metal catalysts by tuning the metal-oxide interface structures. This study explores the hydrogenation of CO to methanol over Cu-supported catalysts, focusing on the synergistic effects of strong metal-support interaction (SMSI) and oxygen vacancies introduced by the CO treatment to the catalysts on the catalytic performance. Cu nanoparticles were immobilized on Mg-Al layered double oxide (LDO) supports and modified with nitrate ions to promote oxygen vacancy generation.
View Article and Find Full Text PDFInvestigating the Synergistic Interactions Between AgNPs and NiCl on the Morpho-Physiological Trajectories of Zea mays L. Through Comprehensive Characterization at Seedling Stage.
Microsc Res Tech
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Green synthesis of nanoparticles (NPs) is preferred for its affordability and environmentally friendly approach. This study explored the synthesis and characterization of silver NPs (AgNPs) and examined their impact on the growth of Zea mays, both alone and in combination with nickel chloride (NiCl). A methanolic leaf extract was combined with silver nitrate to synthesize AgNPs.
View Article and Find Full Text PDFPlant and soil microbial composition legacies following indaziflam herbicide treatment.
Front Microbiol
December 2024
Department of Forestry and Rangeland Stewardship, Colorado State University, Fort Collins, CO, United States.
Land stewards in dryland ecosystems across the western U.S. face challenges to manage the exotic grass (cheatgrass), which is a poor forage, is difficult to remove, and increases risk of catastrophic fire.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!