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Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4.
Int J Biol Sci
December 2024
Zhejiang University School of Medicine, Hangzhou, 310058, China.
ZIP4, a pivotal member of the ZIP family, is the causative gene for the hereditary disorder AE (acrodermatitis enteropathica) in humans, and plays an essential role in regulating zinc ion balance within cells. While research on the molecular structure of ZIP4 continues, there remains a lack of full understanding regarding the stereo-structural conformation of ZIP4 molecules. Currently, there are two hypotheses concerning the transport of zinc ions into the cytoplasm by ZIP4, with some contradictions between experimental studies.
View Article and Find Full Text PDFZinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions.
Psoriasis (Auckl)
November 2024
Department of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai, 200052, People's Republic of China.
Acrodermatitis enteropathica (AE) can be caused by inherited or acquired zinc deficiency, among which site-specific skin lesions or even psoriasiform skin manifestations are present. Few cases exist in the literature involving the diagnosis and treatment of AE overlapped with psoriasiform lesions. In this case, we reported a teenage boy presented characteristic site-specific skin lesions of AE with low serum zinc level, subsequently progressed into generalized pustular psoriasiform manifestations under a genetic background, while a rapid recovery was observed after monotherapy of zinc supplementation.
View Article and Find Full Text PDFAcrodermatitis Enteropathica: A Case Report Involving a Delayed Diagnosis.
Cureus
October 2024
Department of Dermatology, King Abdulaziz Hospital, Makkah, SAU.
Article Synopsis
- A two-year-old girl experienced misdiagnoses such as tinea corporis and psoriasis, leading to ineffective treatments until a proper evaluation revealed her low zinc levels.
- After being diagnosed with AE, she was treated with zinc sulfate, resulting in the complete resolution of her skin lesions within two weeks.
Presentation of a Rare Case of Skin Signs Consistent With Scurvy and Acrodermatitis Enteropathica in the Context of Enolism With Multiple Nutritional Deficiencies.
Actas Dermosifiliogr
October 2024
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. Electronic address:
Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review.
Pediatr Rep
July 2024
Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Article Synopsis
- - Zinc deficiency is a critical health issue for children, leading to a variety of health problems and conditions that can be either acquired or inherited.
- - This overview highlights the different symptoms, diagnostic difficulties, and treatment options for zinc deficiency in children, including issues like skin problems, slow growth, immune dysfunction, and neurological effects.
- - Addressing zinc deficiency requires collaboration among healthcare professionals such as pediatricians, dermatologists, geneticists, and nutritionists to improve care and outcomes for affected children.
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