AI Article Synopsis
- - Control of arteriolar diameters in microvasculature is crucial for balancing oxygen supply and demand in tissues, involving endothelial cells (EC), vascular smooth muscle cells (VSMC), and red blood cells (RBC).
- - All these cell types can respond to signals indicating tissue oxygen needs, with various vasoactive agents having receptors on VSMC, EC, and RBC for coordinated regulation.
- - The text explores how RBC functions (like oxygen transport and release of vasoactive agents) and several signaling pathways connect tissue oxygen demand with the control of VSMC contractility and EC permeability.
Article Abstract
The control of arteriolar diameters in microvasculature has been in the focus of studies on mechanisms matching oxygen demand and supply at the tissue level. Functionally, important vascular elements include EC, VSMC, and RBC. Integration of these different cell types into functional units aimed at matching tissue oxygen supply with tissue oxygen demand is only achieved when all these cells can respond to the signals of tissue oxygen demand. Many vasoactive agents that serve as signals of tissue oxygen demand have their receptors on all these types of cells (VSMC, EC, and RBC) implying that there can be a coordinated regulation of their behavior by the tissue oxygen demand. Such functions of RBC as oxygen carrying by Hb, rheology, and release of vasoactive agents are considered. Several common extra- and intracellular signaling pathways that link tissue oxygen demand with control of VSMC contractility, EC permeability, and RBC functioning are discussed.
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| http://dx.doi.org/10.1111/micc.12052 | DOI Listing |
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