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Assessing the interaction between the N-terminal region of the membrane protein magnesium transporter A and a lipid bilayer.
J Colloid Interface Sci
December 2024
Division of Computational Chemistry, Department of Chemistry, Lund University, P.O. Box 124, Lund, 22100, Sweden. Electronic address:
Unlabelled: This study investigates the interaction of KEIF, the intrinsically disordered N-terminal region of the magnesium transporter MgtA, with lipid bilayers mimicking cell membranes. Combining experimental techniques such as neutron reflectometry (NR), quartz-crystal microbalance with dissipation monitoring (QCM-D), synchrotron radiation circular dichroism (SRCD), and oriented circular dichroism (OCD), with molecular dynamics (MD) simulations, we characterized KEIF's adsorption behavior.
Hypothesis: KEIF undergoes conformational changes upon interacting with lipid bilayers, potentially influencing MgtA's function within the plasma membrane.
Diffusion model assisted designing self-assembling collagen mimetic peptides as biocompatible materials.
Brief Bioinform
November 2024
Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology and School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214222, China.
Collagen self-assembly supports its mechanical function, but controlling collagen mimetic peptides (CMPs) to self-assemble into higher-order oligomers with numerous functions remains challenging due to the vast potential amino acid sequence space. Herein, we developed a diffusion model to learn features from different types of human collagens and generate CMPs; obtaining 66% of synthetic CMPs could self-assemble into triple helices. Triple-helical and untwisting states were probed by melting temperature (Tm); hence, we developed a model to predict collagen Tm, achieving a state-of-art Pearson's correlation (PC) of 0.
View Article and Find Full Text PDFColloidal substrate-facilitated synthesis of gold nanohelices.
J Colloid Interface Sci
December 2024
Institute of Advanced Synthesis (IAS) and School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing Tech University, 30 Puzhu South Road, Nanjing 211816, PR China. Electronic address:
Helical nanostructures have unique optical and mechanical properties, yet their syntheses had always been quite challenging. Various symmetry-breaking mechanisms such as chiral templates, strain-restriction and asymmetric ligand-binding have been developed to induce the helical growth at nanoscale. In this work, with neither chiral ligands nor templates, gold (Au) nanohelices were synthesized via a facile wet-chemical method, through an asymmetric Active Surface Growth facilitated by colloidal silica nanoparticles (NPs).
View Article and Find Full Text PDFNon-Reciprocity, Metastability, and Dynamic Reconfiguration in Co-Assembly of Active and Passive Particles.
Adv Sci (Weinh)
December 2024
Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Article Synopsis
- Living organisms can interact in ways where forces are not equal or opposite, which is often not seen in synthetic systems.
- This study explores how combining non-motile passive particles with motile active particles under an external AC electric field can create complex assemblies and measure the forces between them.
- Results show that different propulsion methods of active particles affect their interactions; for instance, helically propelled active particles create dynamic clusters with adjustable properties, shedding light on designing advanced materials.
Circularly polarized light emission from encapsulated aggregation-induced emission achiral luminogen within the supramolecular helical nanofilament networks.
J Colloid Interface Sci
November 2024
Department of Advanced Materials Engineering for Information & Electronics, Kyung Hee University, Gyeonggi-do 17104, Republic of Korea; Integrated Education Institute for Frontier Science & Technology (BK21 Four), Kyung Hee University, Gyeonggi-do 17104, Republic of Korea. Electronic address:
Article Synopsis
- Circularly polarized light emission (CPLE) materials are gaining interest for applications in areas like spintronics.
- The study demonstrates a new method for activating CPLE in achiral luminogens by utilizing phase separation with helical filaments, which enhances their properties.
- The chiral environment created by nanoscale spaces allows the helical filaments to impart chirality to the otherwise CPLE-inactive luminogens, making this approach a simpler alternative to complex chemical synthesis.
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