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That which does not degrade you makes you stronger: infectivity of poliovirus depends on vesicle acidification. | LitMetric

AI Article Synopsis

  • Research has revealed that viruses interact with autophagy, a key cellular process, in various ways; while autophagy usually helps destroy viruses, some viruses have developed tactics to evade or manipulate this system.
  • * Some viruses can induce autophagy to aid their own replication by inhibiting the degradation of viral particles that would typically be destroyed by the autophagic process.
  • * Recent studies, including work on poliovirus, have shown unexpected aspects of how autophagy can actually enhance virus production, leading to important insights into the relationship between this cellular pathway and viral pathogens.

Article Abstract

Several years ago, an explosion of research into pathogens and autophagy showed that viruses have a wide variety of relationships to this conserved homeostatic pathway. Often, autophagy acts as a host defense mechanism, degrading viruses before they can escape the host cell, and, as such, autophagy is suppressed or avoided by those viruses. A subset of viruses, however, induces and subverts the autophagic machinery to promote their own replication. Many of these viruses inhibit the degradative step in the autophagic pathway, presumably to prevent degradation of cytosolic virions before they exit the cell. Recently, we published a study showing that poliovirus (PV), a well-studied model virus, induces true autophagic degradation. The remainder of our study provided surprising clues about the role of autophagy in promoting virus production. The purpose of this punctum is to discuss the significance of our findings to a general understanding of the autophagic pathway and its relationship to a common class of cellular pathogens.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669197PMC
http://dx.doi.org/10.4161/auto.23962DOI Listing

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