AI Article Synopsis
- Coenzyme Q10 (CoQ10) is an antioxidant used in anti-aging products, known for enhancing skin health.
- Researchers previously found that nano-structured lipid carriers (NLC) around 230 nm improved CoQ10 absorption in the skin compared to similar-sized nanoemulsions.
- This study developed ultra-small NLC with about 80 nm particle sizes, which significantly enhanced the delivery and stability of CoQ10 for better skin permeation.
Article Abstract
Coenzyme Q10 (CoQ10) acts as an antioxidant in the skin and is frequently contained in anti-aging products. In previous studies, it could be shown that nano-structured lipid carriers (NLC) with a size of about 230 nm are beneficial for the dermal delivery of CoQ10. They increased Q10 skin penetration when compared to equally sized nanoemulsion. In this study, ultra-small NLC were prepared with even smaller mean particles sizes of around 80 nm. The influence of this decrease of particle size was investigated in terms of skin permeation and penetration as well as physicochemical stability of the NLC. Improved dermal delivery of CoQ10 by ultra-small NLC could be achieved.
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| http://dx.doi.org/10.1016/j.ijpharm.2013.02.037 | DOI Listing |
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