Recent technological advances have spurred genome-wide studies that afford insights into ribonucleoprotein biology and transcript regulation on an unprecedented scale. Here we review techniques currently used to obtain genome-wide profiles of RNA-protein interactions in living cells. We highlight recent studies of the mRNA-bound proteome and address pitfalls inherent in such investigations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719848 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2013.01.030 | DOI Listing |
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