The molecular mechanisms that regulate functional activation of IL-1α remain elusive. In this issue of Immunity, Zheng et al. (2013) describe a molecular system implicating interleukin-1 receptor-2 (IL-1R2) as a principal cytosolic factor that controls functional IL-1α activation during necrosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637128 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2013.02.001 | DOI Listing |
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