Continuous life-cycle management of veterinary drugs by the Food and Drug Administration Center for Veterinary Medicine (CVM) ensures that safe and effective approved animal drugs are available for use in the United States. This article summarizes basic requirements for the approval of new animal drugs, with a specific focus on the approval of analgesic drugs for use in cattle. CVM encourages drug companies to use innovative approaches to demonstrate the effectiveness of analgesic drugs for cattle. There is an obvious need for continued research into the development of new animal drugs for the control of pain in cattle.
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http://dx.doi.org/10.1016/j.cvfa.2012.11.009 | DOI Listing |
BMJ Open
March 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Objectives: To describe the prevalence and patterns of opioid analgesic and pain medicine dispenses, and the impact of up-scheduling of low-dose (≤15 mg) codeine-containing products to Australians with accepted workers' compensation time loss claims for musculoskeletal conditions between 2010 and 2019.
Design: Interrupted time series.
Setting: Workers' compensation scheme in Victoria, Australia.
Am J Public Health
April 2025
All authors are with the Office of the Chief Medical Examiner, San Francisco, CA. Luke N. Rodda is also with the Department of Laboratory Medicine, University of California, San Francisco.
To identify drug prevalence through the analysis of drug material and paraphernalia (DMP) collected from scenes of fentanyl-involved fatal accidental drug overdoses in San Francisco, California, throughout 2022. We conducted gas chromatography-mass spectrometry testing on 409 items of DMP (e.g.
View Article and Find Full Text PDFSci Adv
March 2025
Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
There is great interest in using genetically tractable organisms such as to gain insights into the regulation and function of sleep. However, sleep phenotyping in has largely relied on simple measures of locomotor inactivity. Here, we present FlyVISTA, a machine learning platform to perform deep phenotyping of sleep in flies.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, People's Republic of China.
6-methyladnosine (mA) modification is present in both positive- and negative-strand RNA of influenza A virus (IAV) and affects the replication and pathogenicity of IAV. However, little is known about the regulatory mechanism of mA in IAV RNA. In the present study, we identified the mA methylation of the viral RNA of different IAV subtypes and confirmed that mA modification promotes the polymerase activity and replication of IAV.
View Article and Find Full Text PDFJ Oncol Pharm Pract
March 2025
Department of Pharmacy Management, Faculty of Pharmacy, Gazi University, 06330, Ankara, Türkiye.
BackgroundOpioid therapy is a critical component in managing pain in palliative care, where pharmacists' specialised expertise is crucial in ensuring quality care for patients. This systematic review aims to document available evidence on pharmacist interventions and their impact on optimising opioid therapy for pain management in palliative care patients.MethodsWe searched Medline (OVID), Embase (OVID), APA PsycINFO and Cochrane Central Register of Controlled Trials (CENTRAL) for relevant articles published from the beginning to 31 December, 2022.
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