[Different types of blood lipoproteins in psoriasis patients. 1. The relationship of dyslipoproteinemias due to disordered cholesterol transport and the course of psoriasis].

Comparison of the course of psoriasis in patients with hypo- and hyperalphacholesterolemia, hypo- and hyperbetacholesterolemia (Type IIA hyperlipoproteinemia) with that in the patients without identified lipid metabolism disturbances has been carried out. Blood lipoproteins were typed in the progressive stage of psoriasis. In hypoalphacholesterolemia patients the period of the psoriatic process stabilization was prolonged. Furthermore the frequency of coming remissions in women correlated (q = 0.90) with the concentration of high density lipoprotein cholesterol. In men similar correlation (q = 0.97) was observed only in the range between the lowest (under 0.5 mmol/l) and the upper thresholds of the mean level (1.4-1.7 mmol/l) of high density lipoprotein cholesterol and then it was undetectable. Type IIA hyperlipoproteinemia had no unfavorable effect on the course of psoriasis. Possible mechanisms responsible for these results are discussed.