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Reflex testing for anti-HDV in HBsAg-positive patients offers high diagnostic yield in a large Central European tertiary care center.
Sci Rep
October 2024
Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Währinger Guertel 18-20, 1090, Vienna, Austria.
Current guidelines recommend reflex testing for hepatitis D virus (HDV) coinfection in hepatitis B surface antigen (HBsAg)-positive patients over risk-factor based screening. We aimed to evaluate the feasibility and diagnostic yield of reflex anti-HDV testing at a Central European tertiary care center. We retrospectively included 560 consecutive patients who had a recorded (first) positive HBsAg test result at the Vienna General Hospital between 2018 and 2022.
View Article and Find Full Text PDFPrevalence of Hepatitis D in People Living with HIV: A National Cross-Sectional Pilot Study.
Viruses
June 2024
School of Medicine, University of Patras, 26504 Patras, Greece.
Article Synopsis
- - This study investigates the prevalence of hepatitis D virus (HDV) among people living with HIV (PLWHIV) in Greece, highlighting the importance of understanding the impact of co-infections on liver disease as new treatments emerge.
- - A total of 696 serum samples from PLWHIV were analyzed, revealing that the majority of participants were male (93%) with a median age of 54 and a long history on antiretroviral therapy, while additional findings showed seroprevalence for other viruses like HCV and HAV.
- - Results showed a low HDV prevalence in the study group, with only 3% testing positive for anti-HDV IgG antibodies and none for HDV RNA, indicating fewer
[Seroprevalence and Risk Factors of Hepatitis B, C and D in Adults in Trabzon, Türkiye].
Mikrobiyol Bul
July 2024
Karadeniz Technical University Faculty of Medicine, Department of Public Health, Trabzon, Türkiye.
Viral hepatitis are infections that can cause liver damage, become chronic, lead to cirrhosis, hepatocellular carcinoma and ultimately result in death due to their ability to spread in the community through blood and infected body fluids. The aim of this study was to determine the seroprevalence of hepatitis B (HBV), hepatitis C (HCV), and hepatitis D (HDV) transmitted through blood among individuals living in Trabzon province and to examine the factors potentially associated with seroprevalence. This cross-sectional study was conducted in Trabzon province, located in the northeast of Türkiye, including a total of 10 districts, including the central district.
View Article and Find Full Text PDFSeroprevalence of hepatitis D virus in Bulgarian outpatients with history of liver dysfunction.
New Microbiol
July 2024
Department of Microbiology and Virology, Varna Medical University, Bulgaria.
The aim of this research was to define the prevalence of antibodies against hepatitis D virus (anti-HDV Ab) in a group of 26 outpatients with liver dysfunction in northeastern Bulgaria. Serum samples were obtained from April 2022 to December 2023 in the "Status" Medical Diagnostic Laboratory, Varna, Bulgaria. We found seroprevalence of anti-HDV Ab in 15.
View Article and Find Full Text PDFArticle Synopsis
- Hepatitis B virus (HBV) and hepatitis delta virus (HDV) co-infection is severe and can be transmitted from mother to child, with significant rates found in pregnant women in Cameroon.
- A study involving 1992 pregnant women revealed a 6.7% prevalence of HBsAg, with 32.3% of HBsAg-positive women also being anti-HDV antibody-positive and almost half showing detectable HDV RNA levels.
- Risk factors linked to HDV presence included multiple pregnancies and body modifications like tattoos, highlighting the need for awareness and preventive measures against maternal transmission of HDV.
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