An efficient reduction of double bonds conjugated with nitrile groups and acid or base sensitive furan rings with 2-phenylbenzimidazoline generated in situ has been successfully accomplished with high yields and excellent selectivity. The employed reducing agent was prepared in one step from ordinary chemicals. The other advantages of the presented method include mild and convenient reaction conditions, a benign and cost effective reagent, simple work-up and separation of the products. As this process does neither affect cyano and nitro groups nor furan rings, it is a valuable alternative when metal-catalyzed hydrogenations or borohydride reductions have failed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270384 | PMC |
| http://dx.doi.org/10.3390/molecules18022212 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting the NLRP3 inflammasome abrogates cardiotoxicity of immune checkpoint blockers.
J Immunother Cancer
January 2025
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many malignant tumors. However, ICI-induced hyper-immune activation causes cardiotoxicity. Traditional treatments such as glucocorticoids and immunosuppressants have limited effectiveness and may even accelerate tumor growth.
View Article and Find Full Text PDFPhotoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi-Substituted Furan Rings via Catalytic Indirect Reductive Quenching.
Chem Asian J
January 2025
Meiji Pharmaceutical University, Pharmaceutical Sciences, 2-522-1 Noshio, 204-8588, Kiyose, JAPAN.
The catalytic indirect reductive quenching method is facilitated by a combination of Ir(III) photoredox and sulfide dual-catalysis system. This study demonstrated a method for synthesizing multi-substituted furans by using a photoredox/sulfide dual-catalysis system. This method enables the synthesis of various furan derivatives, including spirofurans and phthalans.
View Article and Find Full Text PDFBiobased Polyesters with Ultrahigh UV Shielding and Water Degradation Derived from Multifunctional Tetracyclic Diesters.
Biomacromolecules
January 2025
Dalian Key Laboratory of Green Manufacturing Technology for Fine Chemicals Production, College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, P. R. China.
The development of biobased polyesters with the combination of high UV shielding and degradability is a significant challenge. Herein, three 4-membered cyclic monomers containing two pyrrolidone and two furan rings were prepared by the aza-Michael addition of biobased bifuran diamine and dimethyl itaconate (DMI). They were available in melt polycondensation reactions with various diols to synthesize biobased polyesters.
View Article and Find Full Text PDFEffectiveness of dolutegravir-based regimens compared to raltegravir-, elvitegravir-, bictegravir, and darunavir-based regimens among older adults with HIV in the Veterans Aging Cohort Study (VACS).
AIDS Res Ther
December 2024
Veterans Affairs (VA) Connecticut Healthcare System Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), 950 Campbell Avenue, West Haven, CT, 06516-2770, USA.
Background: Real-world data on treatment patterns and clinical outcomes for newer drugs, including integrase strand transfer inhibitors, among older people with human immunodeficiency virus (PWH) are limited.
Methods: This cohort study included PWH enrolled in the Veterans Aging Cohort Study (VACS) who were prescribed a standard 3-drug antiretroviral therapy (ART) regimen containing dolutegravir (DTG), bictegravir (BIC), cobicistat boosted elvitegravir (EVG), raltegravir (RAL), or darunavir/ritonavir (DRV) plus 2 nucleoside reverse transcriptase inhibitors between January 1, 2014, and March 31, 2020, and who were ≥50 years at regimen initiation. The association between regimen and virologic effectiveness or discontinuation was assessed using logistic regression models with inverse probability of treatment weights.
Heteroatom-Based Ligand Engineering of Metal Organic Frameworks for Efficient and Robust Electrochemical Water Oxidation.
ChemSusChem
December 2024
Hunan University, College of Chemistry and Chemical Engineering, CHINA.
Metal-organic frameworks (MOFs) are promising catalysts for the electrochemical oxygen evolution reaction (OER) due to their high surface area, tunable pore structures, and abundant active sites. Ligand engineering is an important strategy to optimize their performance. Here, we report the synthesis of NiFe-MOFs based on three different ligands: 1,4-terephthalic acid (BDC), 2,4-thiophene dicarboxylic acid (TDC), and 2,5-furandicarboxylic acid (FDC), to investigate the effects of heteroatom-based aromatic rings on OER performance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!