6-Oxo and 6-thio analogs of purine were prepared based on the initial activity screening of a small, diverse purine library against Mycobacterium tuberculosis (Mtb). Certain 6-oxo and 6-thio-substituted purine analogs described herein showed moderate to good inhibitory activity. N(9)-substitution apparently enhances the anti-mycobacterial activity in the purine series described herein. Several 2-amino and 2-chloro purine analogs were also synthesized that showed moderate inhibitory activity against Mtb.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612542 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2013.01.054 | DOI Listing |
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