AI Article Synopsis
- The study aims to assess the benefits of using AdGlipr1 gene therapy alongside radiotherapy for treating prostate and bladder cancer in lab models.
- In laboratory tests, the combination therapy showed improved outcomes, such as reduced cancer cell growth and increased cell death, and similar positive results were observed in mice with tumors.
- Results indicate that combining AdGlipr1 with radiotherapy leads to better tumor control and extended survival in these cancer models, particularly with multiple treatment cycles.
Article Abstract
Objectives: The objectives of this study are to explore the potential benefits of combining AdGlipr1 (or AdGLIPR1) gene therapy with radiotherapy using subcutaneous prostate and bladder cancer models.
Materials And Methods: Combination adenoviral vector-mediated gene therapy and radiotherapy were applied to 178-2 BMA and TSU-Pr1 cells in vitro and colony formation and apoptosis were analyzed. In addition, combination therapies were administered to mice bearing subcutaneous 178-2 BMA and TSU-Pr1 tumors, and tumor growth suppression and survival extension were compared with the monotherapies (AdGlipr1/AdGLIPR1 and radiotherapy) or control vector Adv/CMV/βgal, as well as single-cycle treatment with 2-cycle treatment.
Results: Combination treatment significantly suppressed colony formation and increased apoptosis in vitro. In vivo, combination therapy produced significant 178-2 BMA and TSU-Pr1 tumor growth suppression and survival extension compared with the monotherapies or the control. Further tumor growth suppression and survival extension were observed after 2 cycles of the combination treatment.
Conclusions: Combining AdGlipr1 (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors, and additional therapeutic effects may result with repeated treatment cycles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871954 | PMC |
| http://dx.doi.org/10.1016/j.urolonc.2012.10.007 | DOI Listing |
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