A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A 63 year old woman with white matter lesions and pachymeningeal inflammation. | LitMetric

We describe the case of a 63-year-old woman with CNS Rosai-Dorfman disease, presenting with diffuse dural infiltration, mimicking idiopathic hypertrophic pachymeningitis, and right vertebral artery dissection. Her symptoms included a progressive 11-month history of vertigo, gait ataxia, and right thalamic stroke. A diagnosis of CNS Rosai-Dorfman disease was made following open dural biopsy, and later confirmed on autopsy studies. The autopsy demonstrated widespread dural infiltration by inflammatory cells, principally large histiocytes, many of which exhibited emperipolesis, a characteristic finding in Rosai-Dorfman disease. A second pathological finding on autopsy was the presence of multiple demyelinating plaques (with preservation of axons), located in the corpus callosum, periventricular white matter, and multiple brainstem segments. These were consistent with a diagnosis of multiple sclerosis. This case description serves to remind clinicians that CNS Rosai-Dorfman disease—although uncommon—may present as a focal, dural-based, hemispheric mass lesion, or as diffuse pachymeningeal inflammation. Our case was also unusual due to the co-existence of CNS Rosai-Dorfman disease, multiple sclerosis, and polycythemia vera (all rare diseases) in a single patient. Although the overlap of disorders may have been co-incidental, one could raise the question whether all three disorders were triggered by the same underlying dysimmune state.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8029223PMC
http://dx.doi.org/10.1111/bpa.12034DOI Listing

Publication Analysis

Top Keywords

cns rosai-dorfman
16
rosai-dorfman disease
16
white matter
8
pachymeningeal inflammation
8
dural infiltration
8
multiple sclerosis
8
rosai-dorfman
5
year woman
4
woman white
4
matter lesions
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!