AI Article Synopsis
- Herqueiazole (1), herqueioxazole (2), and herqueidiketal (3) are unique polyaromatic metabolites discovered in the marine fungus Penicillium sp.
- The structures of 1 and 2 represent the first known compounds in their categories, with 1 featuring a pyrrole component and 2 containing an oxazole.
- Compound 3 shows moderate cancer cell toxicity and effectively inhibits sortase A, highlighting its potential as a candidate for further medicinal research.
Article Abstract
Herqueiazole (1), herqueioxazole (2), and herqueidiketal (3), polyaromatic metabolites with a novel skeletal class, were isolated from the marine-derived fungus Penicillium sp. Based on the combined spectroscopic analyses, the structures of 1 and 2 were determined to be the first examples of pyrrole- and oxazole-containing phenalenone compounds, respectively, whereas 3 possessed a novel skeleton with a highly oxidized naphthoquinone moiety. Compound 3 exhibited moderate cytotoxicity and significant inhibitory activity against sortase A.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol4002174 | DOI Listing |
Publication Analysis
Top Keywords
polyaromatic metabolites
8
marine-derived fungus
8
fungus penicillium
8
metabolites marine-derived
4
penicillium herqueiazole
4
herqueiazole herqueioxazole
4
herqueioxazole herqueidiketal
4
herqueidiketal polyaromatic
4
metabolites novel
4
novel skeletal
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!