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Cancer vaccine designed from homologous ferritin-based fusion protein with enhanced DC-T cell crosstalk for durable adaptive immunity against tumors.
Bioact Mater
April 2025
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, PR China.
Peptide vaccines based on tumor antigens face the challenges of rapid clearance of peptides, low immunogenicity, and immune suppressive tumor microenvironment. However, the traditional solution mainly uses exogenous substances as adjuvants or carriers to enhance innate immune responses, but excessive inflammation can damage adaptive immunity. In the current study, we propose a straightforward novel nanovaccine strategy by employing homologous human ferritin light chain for minimized innate immunity and dendritic cell (DC) targeting, the cationic KALA peptide for enhanced cellular uptake, and suppressor of cytokine signaling 1 (SOCS1) siRNA for modulating DC activity.
View Article and Find Full Text PDFSelf-Activated Energy Release Cascade from Anthracene-Based Solid-State Molecular Solar Thermal Energy Storage Systems.
Chem
November 2024
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA.
We introduce donor-acceptor substituted anthracenes as effective molecular solar thermal energy storage compounds that operate exclusively in the solid state. The donor-acceptor anthracenes undergo visible light-induced [4+4] cycloaddition reaction, producing metastable cycloadducts, dianthracenes with quaternary carbons, and storing photon energy. The triggered cycloreversion of dianthracenes to anthracenes discharges the stored energy as heat in the order of 100 kJ/mol (200 J/g).
View Article and Find Full Text PDFPhosphor-converted light-emitting diodes in the marine environment: current status and future trends.
Chem Sci
January 2025
Zhuhai Key Laboratory of Optoelectronic Functional Materials and Membrane Technology, School of Chemical Engineering and Technology, Sun Yat-sen University Zhuhai 519082 P. R. China
The exploitation and utilization of resources in marine environments have ignited a demand for advanced illumination and optical communication technologies. Light-emitting diodes (LEDs), heralded as "green lighting sources", offer a compelling solution to the technical challenges of marine exploration due to their inherent advantages. Among the myriad of LED technologies, phosphor-converted light-emitting diodes (pc-LEDs) have emerged as frontrunners in marine applications.
View Article and Find Full Text PDFA Comprehensive Assessment of the Marginal Abatement Costs of CO of Co-Optima Multi-Mode Vehicles.
Energy Fuels
January 2025
Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99354, United States.
The Co-Optimization of Fuels and Engines (Co-Optima) is a research and development consortia funded by the U.S. Department of Energy, which has engaged partners from national laboratories, universities, and industry to conduct multidisciplinary research at the intersection of biofuels and combustion sciences.
View Article and Find Full Text PDFLight People: Prof. Henry Snaith's (FRS) perovskite optoelectronics journey.
Light Sci Appl
January 2025
Executive Management College of CHN ENERGY, No.7 Binhe Avenue, North District of Future Science City, Changping District, Beijing, 102211, China.
In 2012, Prof. Henry Snaith demonstrated the first solid-state perovskite solar cell (PSC) with an efficiency of 10.9%, igniting a surge of interest and research into perovskite materials for their potential to revolutionize the photovoltaic (PV) industry.
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