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Severe imipramine-induced myoclonus in a patient with psychotic bipolar depression, catatonia, and schizencephaly.
Ann Clin Psychiatry
March 1994
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110.
Mild myoclonus is reasonably common with various cyclic antidepressants. However, antidepressants rarely cause severe myoclonus, and no risk or predisposing factors have been reported in the literature. We report a case of exceptionally severe myoclonus developing at therapeutic doses and modest serum levels of imipramine.
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