A 19-year-old man presented with a right testicular swelling. Testicular ultrasound demonstrated areas suspicious for malignancy and so it was decided to proceed for a right radical inguinal orchiectomy. Initial histological examination revealed a multiloculated cystic lesion at the area of the rete testis yet normal testicular parenchyma elsewhere. Specialist histological opinion was sought from the regional teratoma multi-disciplinary team which confirmed the diagnosis of a sertoliform cystadenoma, an extremely rare benign testicular neoplasm. The recognition of the benign nature of the mass enabled complete reassurance to be offered to the patient and avoided further oncological treatment.
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| http://dx.doi.org/10.1136/bcr-2012-008439 | DOI Listing |
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Compared to the WHO classification of the male genital tumors in 2016, minimal changes were introduced in the current WHO 2022. Classification of germ cell tumors remains the same as in the previous edition, dividing germ cell tumors into those derived from germ cell neoplasia in situ (GCNIS) and those independent of GCNIS. The group of GCNIS derived germ cell tumors is essentially unchanged.
View Article and Find Full Text PDFSex cord stromal tumors and tumors of the paratestis: new and old entities in a landscape of rare tumors.
Curr Opin Urol
July 2022
Department of Pathology, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Article Synopsis
- The 5th edition of WHO classification updates important information about tumors in the male genitourinary tract, specifically focusing on new entities like Signet-ring stromal tumors (SRST) and myoid gonadal stromal tumors (MGST).
- Both SRST and MGST have shown benign behavior post-surgery, with a recommendation for conservative surgical approaches, and there's a goal to form larger case studies to explore their characteristics further.
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An introduction to the WHO 5th edition 2022 classification of testicular tumours.
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Memorial Sloan-Kettering Cancer Center, Pathology, New York, NY, USA.
The 5th edition of the World Health Organisation Blue Book was published recently and includes a comprehensive update on testicular tumours. This builds upon the work of the 4th edition, retaining its structure and main nomenclature, including the use of the term 'germ cell neoplasia in situ' (GCNIS) for the pre-invasive lesion of most germ cell tumours and division from those not derived from GCNIS. While there have been important developments in understanding the molecular underpinnings of testicular cancer, this updated classification paradigm and approach remains rooted in morphology.
View Article and Find Full Text PDFIntroduction: Sertoliform cystadenoma is a very rare, benign lesion of the rete-testis difficult to distinguish from other malignancies of the testicle.
Case Presentation: We present the case of a 42-year-old male who presented with a right testicular mass, asymptomatic for 1 year. Clinical examination revealed a palpable, painless, and well-delimited right testicular superior pole nodule.
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