AI Article Synopsis
- Researchers aimed to find new treatment targets for coronary artery disease (CAD) by studying fasting serum levels of apolipoprotein B48 (apoB48) as a potential marker.
- They compared serum LDL-C levels and apoB48 concentrations in patients with new-onset CAD, chronic CAD, and those without CAD, finding apoB48 to be significantly higher in CAD patients.
- The study concluded that apoB48 not only serves as a marker for CAD but also independently predicts the progression of coronary lesions, regardless of other conventional risk factors.
Article Abstract
Background: To identify new therapeutic targets for coronary artery disease (CAD), we investigated whether fasting serum concentration of apolipoprotein (apo) B48 could be a marker for CAD.
Methods: Patients with CAD were divided into those with new-onset CAD [i.e., those receiving percutaneous coronary intervention (PCI) for the first time] and those with chronic CAD (i.e., those receiving follow-up coronary angiography). Fasting serum biochemical analyses were performed on admission and 6 months after the PCI.
Results: On admission, serum LDL-C concentrations in patients with chronic CAD (n=138), presumably receiving statin treatment, were lower than in patients with new-onset CAD (n=50, p<0.02) or without CAD (n=71, p<0.001). Nevertheless, apoB48 was higher in CAD patients than in those without CAD (p<0.001). After adjusting for classic cardiovascular risk factors, multivariate logistic regression analyses showed apoB48 to be an independent predictor of coronary risk in new-onset or chronic CAD, irrespective of the LDL-C levels. Moreover, apoB48 was markedly increased during the follow-up period in CAD patients having new lesion progression after the prior PCI.
Conclusion: Fasting serum apoB48 concentration could be a marker of new onset as well as chronic CAD, and predict new lesion progression in secondary prevention.
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| http://dx.doi.org/10.1016/j.cca.2013.02.005 | DOI Listing |
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